Studying the mononuclear phagocyte system in the molecular age

被引：227

作者：

Chow, Andrew ^{[1
,2
]}

Brown, Brian D. ^{[3
,4
]}

Merad, Miriam ^{[1
,2
,3
,5
]}

机构：

[1] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA

[4] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA

[5] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY 10029 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 11期

基金：

美国国家卫生研究院;

关键词：

GREEN FLUORESCENT PROTEIN; IN-VIVO DEPLETION; CONDITIONAL MACROPHAGE ABLATION; SUBCAPSULAR SINUS MACROPHAGES; STIMULATING FACTOR-1 RECEPTOR; CD11C(+) DENDRITIC CELLS; CD8(+) T-CELLS; ALVEOLAR MACROPHAGES; LANGERHANS CELLS; KINASE INHIBITOR;

D O I：

10.1038/nri3087

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability and myeloid classification; however, the factors that regulate the differentiation, homeostasis and function of macrophages and dendritic cells remain largely unknown. The purpose of this manuscript is to review the tools that are currently available and those that are under development to study the origin and function of mononuclear phagocytes.

引用

页码：788 / 798

页数：11

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