Stem Cell Heterogeneity and Plasticity in Epithelia

被引：134

作者：

Donati, Giacomo ^{[1
]}

Watt, Fiona M. ^{[1
]}

机构：

[1] Kings Coll London, Ctr Stem Cells & Regenerat Med, London SE1 9RT, England

来源：

CELL STEM CELL | 2015年 / 16卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金; 英国医学研究理事会;

关键词：

TRANSIT-AMPLIFYING CELLS; DNA METHYLATION DYNAMICS; HUMAN EPIDERMAL STEM; PROGENITOR CELLS; IN-VIVO; GENE-EXPRESSION; TISSUE REGENERATION; SMALL-INTESTINE; MAMMARY-GLAND; HUMAN COLON;

D O I：

10.1016/j.stem.2015.04.014

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Epithelia cover the surfaces and line the cavities of the body. Recent studies have highlighted the existence of multiple stem cell compartments within individual epithelia that exhibit striking plasticity in response to tissue damage, transplantation, or tumor development. New knowledge about the composition of the epithelial niche and the transcription factor networks that maintain cell identity has provided new insights into the extrinsic and intrinsic regulation of stem cell behavior. In addition new in vitro tissue substitutes allow better integration of data from human and mouse models.

引用

页码：465 / 476

页数：12

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