Neuregulin 1 and schizophrenia

被引：110

作者：

Stefansson, H ^{[1
]}

Steinthorsdottir, V ^{[1
]}

Thorgeirsson, TE ^{[1
]}

Gulcher, JR ^{[1
]}

Stefansson, K ^{[1
]}

机构：

[1] deCODE Genet, CNS Div, IS-101 Reykjavik, Iceland

来源：

ANNALS OF MEDICINE | 2004年 / 36卷 / 01期

关键词：

association; developmental; dopaminergic; glutamatergic; haplotype analysis; linkage analysis; neuregulin; 1; NMDA; schizophrenia; synaptic plasticity;

D O I：

10.1080/07853890310017585

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We discuss in this review the role of the neuregulin (NRG1) gene in schizophrenia. NRG1 contributes to the genetics of schizophrenia in both Icelandic and Scottish schizophrenia patients. NRG1 participates in glutamatergic signaling by regulating the N-methyl-D-aspartate (NMDA) receptor through the interaction of. the NRG1 protein and its receptors. NRG1 plays a central role in neural development and is most likely involved in regulating synaptic plasticity, or how the brain responds or adapts to the environment. The discovery that defects in NRG1 signaling may be involved in some cases of schizophrenia, not only implicates NRG1, but suggests that its biological pathway, active both at developing and mature synapses, is worth inspecting further in a search for other schizophrenia genes possibly in epistasis with NRG1.

引用

页码：62 / 71

页数：10

共 92 条

[1]

Adlkofer K, 2000, GLIA, V29, P104, DOI 10.1002/(SICI)1098-1136(20000115)29:2<104::AID-GLIA2>3.0.CO

[2]

2-2

[3] NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity [J].

Ali, DW ;

Salter, MW .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (03) :336-342

[4]

Anton ES, 1997, DEVELOPMENT, V124, P3501

[5]

Arvanov VL, 1997, J PHARMACOL EXP THER, V283, P226

[6] Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents [J].

Ashe, PC ;

Berry, MD ;

Boulton, AA .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2001, 25 (04) :691-707

[7] Back signaling by the Nrg-1 intracellular domain [J].

Bao, JX ;

Wolpowitz, D ;

Role, LW ;

Talmage, DA .

JOURNAL OF CELL BIOLOGY, 2003, 161 (06) :1133-1141

[8] Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21 [J].

Blouin, JL ;

Dombroski, BA ;

Nath, SK ;

Lasseter, VK ;

Wolyniec, PS ;

Nestadt, G ;

Thornquist, M ;

Ullrich, G ;

McGrath, J ;

Kasch, L ;

Lamacz, M ;

Thomas, MG ;

Gehrig, C ;

Radhakrishna, U ;

Snyder, SE ;

Balk, KG ;

Neufeld, K ;

Swartz, KL ;

DeMarchi, N ;

Papadimitriou, GN ;

Dikeos, DG ;

Stefanis, CN ;

Chakravarti, A ;

Childs, B ;

Housman, DE ;

Kazazian, HH ;

Antonarakis, SE ;

Pulver, AE .

NATURE GENETICS, 1998, 20 (01) :70-73

[9]

Brzustowicz LM, 1999, AM J HUM GENET, V65, P1096, DOI 10.1086/302579

[10] Neuregulin and ErbB receptor signaling pathways in the nervous system [J].

Buonanno, A ;

Fischbach, GD .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (03) :287-296

← 1 2 3 4 5 6 7 8 9 10 →