The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance

被引：121

作者：

Dietrich, A ^{[1
]}

Kalwa, H ^{[1
]}

Rost, BR ^{[1
]}

Gudermann, T ^{[1
]}

机构：

[1] Univ Marburg, Inst Pharmakol & Toxikol, D-35043 Marburg, Germany

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2005年 / 451卷 / 01期

关键词：

DAG-sensitive TRPC3; TRPC6; TRPC7; non-selective cation channels; functional characterization; physiological function; smooth muscle cells; pulmonary arterial hypertension; Bayliss effect;

D O I：

10.1007/s00424-005-1460-0

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Among the "classical" or "canonical" transient receptor potential (TRPC) family, the TRPC3, -6, and -7 channels share 75% amino acid identity and are gated by exposure to diacylglycerol. TRPC3, TRPC6, and TRPC7 interact physically and coassemble to form functional tetrameric channels. This review focuses on the TRPC3/6/7 subfamily and describes their functional properties and regulation as homomers obtained from overexpression studies in cell lines. It also summarizes their heteromultimerization potential in vitro and in vivo and presents initial data concerning their physiological functions analyzed in isolated tissues with downregulated channel activity and gene-deficient mouse models.

引用

页码：72 / 80

页数：9

共 88 条

[1] Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells [J].

Balzer, M ;

Lintschinger, B ;

Groschner, K .

CARDIOVASCULAR RESEARCH, 1999, 42 (02) :543-549

[2] Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells -: Role in apical Ca2+ influx [J].

Bandyopadhyay, BC ;

Swaim, WD ;

Liu, XB ;

Redman, RS ;

Patterson, RL ;

Ambudkar, IS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (13) :12908-12916

[3] 20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells [J].

Basora, N ;

Boulay, G ;

Bilodeau, L ;

Rousseau, E ;

Payet, MD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (34) :31709-31716

[4]

Beech DJ, 2004, J PHYSIOL-LONDON, V559, P685, DOI 10.1113/jphysiol.2004.068734

[5] Elementary and global aspects of calcium signalling [J].

Berridge, MJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 499 (02) :291-306

[6] Rapid vesicular translocation and insertion of TRP channels [J].

Bezzerides, VJ ;

Ramsey, IS ;

Kotecha, S ;

Greka, A ;

Clapham, DE .

NATURE CELL BIOLOGY, 2004, 6 (08) :709-720

[7] Ca2+-calmodulin regulates receptor-operated Ca2+ entry activity of TRPC6 in HEK-293 cells [J].

Boulay, G .

CELL CALCIUM, 2002, 32 (04) :201-207

[8] Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP):: Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry [J].

Boulay, G ;

Brown, DM ;

Qin, N ;

Jiang, MS ;

Dietrich, A ;

Zhu, MX ;

Chen, ZG ;

Birnbaumer, M ;

Mikoshiba, K ;

Birnbaumer, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14955-14960

[9] Cloning and expression of a novel Mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the G(q) class of G protein [J].

Boulay, G ;

Zhu, X ;

Peyton, M ;

Jiang, MS ;

Hurst, R ;

Stefani, E ;

Birnbaumer, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (47) :29672-29680

[10] Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation [J].

Cayouette, S ;

Lussier, MP ;

Mathieu, EL ;

Bousquet, SM ;

Boulay, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (08) :7241-7246

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