The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance

被引：121

作者：

Dietrich, A ^{[1
]}

Kalwa, H ^{[1
]}

Rost, BR ^{[1
]}

Gudermann, T ^{[1
]}

机构：

[1] Univ Marburg, Inst Pharmakol & Toxikol, D-35043 Marburg, Germany

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2005年 / 451卷 / 01期

关键词：

DAG-sensitive TRPC3; TRPC6; TRPC7; non-selective cation channels; functional characterization; physiological function; smooth muscle cells; pulmonary arterial hypertension; Bayliss effect;

D O I：

10.1007/s00424-005-1460-0

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Among the "classical" or "canonical" transient receptor potential (TRPC) family, the TRPC3, -6, and -7 channels share 75% amino acid identity and are gated by exposure to diacylglycerol. TRPC3, TRPC6, and TRPC7 interact physically and coassemble to form functional tetrameric channels. This review focuses on the TRPC3/6/7 subfamily and describes their functional properties and regulation as homomers obtained from overexpression studies in cell lines. It also summarizes their heteromultimerization potential in vitro and in vivo and presents initial data concerning their physiological functions analyzed in isolated tissues with downregulated channel activity and gene-deficient mouse models.

引用

页码：72 / 80

页数：9

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