Novel approach for fetal heart rate classification introducing grammatical evolution

Fetal heart rate (FHR) variations reflect the level of oxygenation and blood pressure of the fetus. Electronic Fetal Monitoring (EFM), the continuous monitoring of the FHR, was introduced into clinical practice in the late 1960s and since then it has been considered as an indispensable tool for fetal surveillance. However, EFM evaluation and its merit is still an open field of controversy, mainly because it is not consistently reproducible and effective. In this work, we present a novel method based on grammatical evolution to discriminate acidemic from normal fetuses, utilizing features extracted from the FHR signal during the minutes immediately preceding delivery. The proposed method identifies linear and nonlinear correlations among the originally extracted features and creates/constructs a set of new ones, which, in turn, feed a nonlinear classifier. The classifier, which also uses a hybrid method for training, along with the constructed features was tested using a set of real data achieving an overall performance of 90% (specificity = sensitivity = 90%). (C) 2007 Elsevier Ltd. All rights reserved.