ONYX-015: Clinical data are encouraging

[1] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J]. SCIENCE, 1996, 274 (5286) : 373 - 376

[2] A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy [J]. HUMAN GENE THERAPY, 1998, 9 (09) : 1323 - 1333

[3] The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle [J]. JOURNAL OF VIROLOGY, 1997, 71 (01) : 548 - 561

[4] p53-dependent cell death apoptosis is required for a productive adenovirus infection [J]. NATURE MEDICINE, 1998, 4 (09) : 1068 - 1072

[5] ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents [J]. NATURE MEDICINE, 1997, 3 (06) : 639 - 645

[6] KIRN D, 1998, P AN M AM SOC CLIN, V17, P1509

[7] Killing tumor cells with viruses - a question of specificity [J]. NATURE MEDICINE, 1998, 4 (09) : 1012 - 1013

[8] Cancer - Has the smart bomb been defused? [J]. NATURE, 1998, 395 (6697) : 13 - +

[9] Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis [J]. JOURNAL OF VIROLOGY, 1996, 70 (09) : 6207 - 6215

[10] SUBRAMANIAN T, 1984, J BIOL CHEM, V259, P1777

[1] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J]. SCIENCE, 1996, 274 (5286) : 373 - 376

[2] A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy [J]. HUMAN GENE THERAPY, 1998, 9 (09) : 1323 - 1333

[3] The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle [J]. JOURNAL OF VIROLOGY, 1997, 71 (01) : 548 - 561

[4] p53-dependent cell death apoptosis is required for a productive adenovirus infection [J]. NATURE MEDICINE, 1998, 4 (09) : 1068 - 1072

[5] ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents [J]. NATURE MEDICINE, 1997, 3 (06) : 639 - 645

[6] KIRN D, 1998, P AN M AM SOC CLIN, V17, P1509

[7] Killing tumor cells with viruses - a question of specificity [J]. NATURE MEDICINE, 1998, 4 (09) : 1012 - 1013

[8] Cancer - Has the smart bomb been defused? [J]. NATURE, 1998, 395 (6697) : 13 - +

[9] Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis [J]. JOURNAL OF VIROLOGY, 1996, 70 (09) : 6207 - 6215

[10] SUBRAMANIAN T, 1984, J BIOL CHEM, V259, P1777