The talin wags the dog: new insights into integrin activation

被引：30

作者：

Cram, EJ ^{[1
]}

Schwarzbauer, JE ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.tcb.2003.12.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.

引用

页码：55 / 57

页数：3

共 24 条

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