共 34 条
Microarray technology in the study of obesity and non-alcoholic fatty liver disease
被引:14
作者:

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Schlauch, K
论文数: 0 引用数: 0
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机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Gowder, S
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Collantes, R
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Chandhoke, V
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Younossi, ZM
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA
机构:
[1] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA
[2] George Mason Univ, Ctr Study Genom Liver Dis, Mol & Microbiol Dept, Fairfax, VA 22030 USA
关键词:
gene expression;
microarray;
NAFLD;
obesity;
D O I:
10.1111/j.1478-3231.2005.01183.x
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
The recent development of high-throughput gene expression technology permits simultaneous investigation of thousands of genes, providing a snapshot of the transcription state of diseased tissue. Microarray-based expression profiling is well suited to investigate the molecular basis of complex diseases such as obesity and chronic liver disease. With the help of microarray technology, functional genomics will surely advance our understanding of these diseases, and lead to more effective, targeted interventions that lack the toxicity of many conventional treatments. Despite their tremendous potential, microarray studies are subject to potential flaws in experimental design, experimental techniques, data analysis, and data interpretation. Besides the technical issues, the most important challenge is to develop integrative databases that combine gene expression data with the clinical data. Over the next few years, advances in technology and refinements in study design and data analysis will make clinically relevant translational research even more engaging and productive.
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页码:1091 / 1096
页数:6
相关论文
共 34 条
[1]
Nonalcoholic fatty liver disease
[J].
Brunt, Elizabeth M.
;
Wong, Vincent W. -S.
;
Nobili, Valerio
;
Day, Christopher P.
;
Sookoian, Silvia
;
Maher, Jacquelyn J.
;
Bugianesi, Elisabetta
;
Sirlin, Claude B.
;
Neuschwander-Tetri, BrentA.
;
Rinella, Mary E.
.
NATURE REVIEWS DISEASE PRIMERS,
2015, 1

Brunt, Elizabeth M.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

Wong, Vincent W. -S.
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
Chinese Univ Hong Kong, State Key Lab Digest Dis, Hong Kong, Hong Kong, Peoples R China Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

Nobili, Valerio
论文数: 0 引用数: 0
h-index: 0
机构:
Bambino Gesu Children Hosp, Hepatometab Unit, Rome, Italy Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

Day, Christopher P.
论文数: 0 引用数: 0
h-index: 0
机构:
Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

论文数: 引用数:
h-index:
机构:

Maher, Jacquelyn J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, San Francisco, CA 94110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

Bugianesi, Elisabetta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Torino Citta Salute & Sci, Dept Med Sci, Turin, Italy Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

Sirlin, Claude B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Radiol, Liver Imaging Grp, San Diego, CA 92103 USA Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

Neuschwander-Tetri, BrentA.
论文数: 0 引用数: 0
h-index: 0
机构:
St Louis Univ, Sch Med, Div Gastroenterol & Hepatol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

Rinella, Mary E.
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA Washington Univ, Sch Med, Dept Pathol & Immunol, 660 Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA
[2]
Obesity-related differential gene expression in the visceral adipose tissue
[J].
Baranova, A
;
Collantes, R
;
Gowder, SJ
;
Elariny, H
;
Schlauch, K
;
Younoszai, A
;
King, S
;
Randhawa, M
;
Pusulury, S
;
Alsheddi, T
;
Ong, JP
;
Martin, LM
;
Chandhoke, V
;
Younossi, ZM
.
OBESITY SURGERY,
2005, 15 (06)
:758-765

论文数: 引用数:
h-index:
机构:

Collantes, R
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Gowder, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Elariny, H
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Schlauch, K
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Younoszai, A
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

King, S
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Randhawa, M
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Pusulury, S
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Alsheddi, T
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Ong, JP
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Martin, LM
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Chandhoke, V
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA

Younossi, ZM
论文数: 0 引用数: 0
h-index: 0
机构: Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA
[3]
Microarrays: the use of oligonucleotides and cDNA for the analysis of gene expression
[J].
Barrett, JC
;
Kawasaki, ES
.
DRUG DISCOVERY TODAY,
2003, 8 (03)
:134-141

Barrett, JC
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Ctr Canc Res, Bethesda, MD 20892 USA

Kawasaki, ES
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Ctr Canc Res, Bethesda, MD 20892 USA
[4]
Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees
[J].
Bigger, CB
;
Guerra, B
;
Brasky, KM
;
Hubbard, G
;
Beard, MR
;
Luxon, BA
;
Lemon, SM
;
Lanford, RE
.
JOURNAL OF VIROLOGY,
2004, 78 (24)
:13779-13792

Bigger, CB
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA

Guerra, B
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA

Brasky, KM
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA

Hubbard, G
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA

Beard, MR
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA

Luxon, BA
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA

Lemon, SM
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA

Lanford, RE
论文数: 0 引用数: 0
h-index: 0
机构: SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA
[5]
Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects
[J].
Clément, K
;
Viguerie, N
;
Poitou, C
;
Carette, C
;
Pelloux, V
;
Curat, CA
;
Sicard, A
;
Rome, S
;
Benis, A
;
Zucker, JD
;
Vidal, H
;
Laville, M
;
Barsh, GS
;
Basdevant, A
;
Stich, V
;
Cancello, R
;
Langin, D
.
FASEB JOURNAL,
2004, 18 (14)
:1657-1669

Clément, K
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Viguerie, N
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

论文数: 引用数:
h-index:
机构:

Carette, C
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

论文数: 引用数:
h-index:
机构:

Curat, CA
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Sicard, A
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Rome, S
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Benis, A
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Zucker, JD
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Vidal, H
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Laville, M
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Barsh, GS
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Basdevant, A
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Stich, V
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Cancello, R
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France

Langin, D
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, Dept Nutr, INSERM, Dept Nutr,AP HP, F-75181 Paris 04, France
[6]
Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
[J].
Crespo, J
;
Cayón, A
;
Fernández-Gil, P
;
Hernández-Guerra, M
;
Mayorga, M
;
Domínguez-Díez, A
;
Fernández-Escalante, JC
;
Pons-Romero, F
.
HEPATOLOGY,
2001, 34 (06)
:1158-1163

Crespo, J
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain

Cayón, A
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain

Fernández-Gil, P
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain

Hernández-Guerra, M
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain

Mayorga, M
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain

Domínguez-Díez, A
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain

Fernández-Escalante, JC
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain

Pons-Romero, F
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Marques Valdecilla, Serv Aparato Digest, Inst Digest Dis, Sch Med, E-39008 Santander, Cantabria, Spain
[7]
Sample size determination in microarray experiments for class comparison and prognostic classification
[J].
Dobbin, K
;
Simon, R
.
BIOSTATISTICS,
2005, 6 (01)
:27-38

Dobbin, K
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Biometr Res Branch, Bethesda, MD 20892 USA NCI, Biometr Res Branch, Bethesda, MD 20892 USA

Simon, R
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Biometr Res Branch, Bethesda, MD 20892 USA NCI, Biometr Res Branch, Bethesda, MD 20892 USA
[8]
Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and Adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
[J].
Fain, JN
;
Madan, AK
;
Hiler, ML
;
Cheema, P
;
Bahouth, SW
.
ENDOCRINOLOGY,
2004, 145 (05)
:2273-2282

Fain, JN
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Mol Sci, Memphis, TN 38163 USA Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Mol Sci, Memphis, TN 38163 USA

Madan, AK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Mol Sci, Memphis, TN 38163 USA

Hiler, ML
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Mol Sci, Memphis, TN 38163 USA

Cheema, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Mol Sci, Memphis, TN 38163 USA

Bahouth, SW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Mol Sci, Memphis, TN 38163 USA
[9]
High prevalence of metabolic complications in patients with non-alcoholic fatty liver disease
[J].
Friis-Liby, I
;
Aldenborg, F
;
Jeristad, P
;
Rundstörm, K
;
Björnsson, E
.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,
2004, 39 (09)
:864-869

Friis-Liby, I
论文数: 0 引用数: 0
h-index: 0
机构:
Sahlgrens Univ Hosp, Dept Internal Med, Sect Gastroenterol & Hepatol, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Internal Med, Sect Gastroenterol & Hepatol, SE-41345 Gothenburg, Sweden

Aldenborg, F
论文数: 0 引用数: 0
h-index: 0
机构: Sahlgrens Univ Hosp, Dept Internal Med, Sect Gastroenterol & Hepatol, SE-41345 Gothenburg, Sweden

Jeristad, P
论文数: 0 引用数: 0
h-index: 0
机构: Sahlgrens Univ Hosp, Dept Internal Med, Sect Gastroenterol & Hepatol, SE-41345 Gothenburg, Sweden

Rundstörm, K
论文数: 0 引用数: 0
h-index: 0
机构: Sahlgrens Univ Hosp, Dept Internal Med, Sect Gastroenterol & Hepatol, SE-41345 Gothenburg, Sweden

Björnsson, E
论文数: 0 引用数: 0
h-index: 0
机构: Sahlgrens Univ Hosp, Dept Internal Med, Sect Gastroenterol & Hepatol, SE-41345 Gothenburg, Sweden
[10]
The ins and outs of mitochondrial dysfunction in NASH
[J].
Fromenty, B
;
Robin, M
;
Igoudjil, A
;
Mansouri, A
;
Pessayre, D
.
DIABETES & METABOLISM,
2004, 30 (02)
:121-138

Fromenty, B
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM U481, F-75018 Paris, France Univ Paris 07, INSERM U481, F-75018 Paris, France

Robin, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM U481, F-75018 Paris, France Univ Paris 07, INSERM U481, F-75018 Paris, France

Igoudjil, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM U481, F-75018 Paris, France Univ Paris 07, INSERM U481, F-75018 Paris, France

Mansouri, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM U481, F-75018 Paris, France Univ Paris 07, INSERM U481, F-75018 Paris, France

Pessayre, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM U481, F-75018 Paris, France Univ Paris 07, INSERM U481, F-75018 Paris, France