Symptoms and well-being in relation to glycemic control in type II diabetes

被引:193
作者
VanderDoes, FEE
DeNeeling, JND
Snoek, FJ
Kostense, PJ
Grootenhuis, PA
Bouter, LM
Heine, RJ
机构
[1] Inst. for Res. in Extramural Med., Vrije Universiteu, Amsterdam
[2] EMGO Institute, Vrije Universiteit, NL-1081 BT Amsterdam
关键词
D O I
10.2337/diacare.19.3.204
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - To describe the cross-sectional relation between glycemic control and physical symptoms, emotional well-being, and general well-being in patients with type II diabetes. RESEARCH DESIGN AND METHODS - The study population consisted of 188 patients with type II diabetes between 40 and 75 years of age. Patients were treated with blood glucose-lowering agents or had either a fasting venous plasma glucose level greater than or equal to 7.8 mmol/l or an HbA(1)c level >6.1%. Multiple regression analyses were performed. Dependent variables were scores on the Type II Diabetes Symptom Checklist, the Profile of Mood Slates, the Affect Balance Scale, and questions regarding general well-being. The primary determinant under study was HbA(1c). In addition, age, sex, neuroticism (indicating a general tendency to complain), insulin use, and comorbidity were included as determinants in all analyses. Other potential determinants taken into consideration were hypoglycemic complaints, marital status, diabetes duration, cardiovascular history, blood pressure, BMI, waist-to-hip ratio, perceived burden of treatment, and smoking. None of these potential determinants had to be included to correct confounding of the relation between HbA(1c) and well-being scores. RESULTS - Higher HbA,, levels were significantly associated with higher symptom scores (total score, hyperglycemic score, and neuropathic score), with worse mood (total score, displeasure score, depression, tension, fatigue), and with worse general well-being. The relative risks varied between 1.02 and 1.36 for each percentage difference in HbA(1c). The relation between HbA(1c) and some mood states was modified by neuroticism: in the less neurotic patient (i.e,, one who is less inclined to complain), the relation was more evident. CONCLUSIONS - These data suggest that better glycemic control in type II diabetes is associated with fewer physical symptoms, better mood, and better well-being, in a nonhypoglycemic HbA(1c) range.
引用
收藏
页码:204 / 210
页数:7
相关论文
共 23 条
  • [11] LUTEIJN F, 1985, HANDLEIDING BIJ NEDE
  • [12] PSYCHOLOGICAL AND SOCIAL CORRELATES OF GLYCEMIC CONTROL
    MAZZE, RS
    LUCIDO, D
    SHAMOON, H
    [J]. DIABETES CARE, 1984, 7 (04) : 360 - 366
  • [13] ON THE MEASUREMENT OF HAPPINESS - AN EXAMINATION OF THE BRADBURN SCALE IN THE CANADA HEALTH SURVEY
    MCDOWELL, I
    PRAUGHT, E
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1982, 116 (06) : 949 - 958
  • [14] McNair D. MM., 1971, Manual for the Profile of Mood States (POMS)
  • [15] MILES P, 1994, 54 P ANN M AM DIAB A
  • [16] TYPE-2 DIABETES AND DEPRESSIVE SYMPTOMS IN OLDER ADULTS - A POPULATION-BASED STUDY
    PALINKAS, LA
    BARRETTCONNOR, E
    WINGARD, DL
    [J]. DIABETIC MEDICINE, 1991, 8 (06) : 532 - 539
  • [17] Prospective U. K., 1991, DIABETOLOGIA, V34, P877
  • [18] PSYCHOLOGICAL-PROBLEMS IN DIABETICS WITH SECONDARY FAILURE OF SULFONYLUREAS
    RATZMANN, KP
    [J]. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1991, 116 (03) : 87 - 90
  • [19] DELAYED DIAGNOSIS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
    SINGH, BM
    JACKSON, DMA
    WILLS, R
    DAVIES, J
    WISE, PH
    [J]. BRITISH MEDICAL JOURNAL, 1992, 304 (6835) : 1154 - 1155
  • [20] SWAIN CT, 1994, DIABETES S1, V43, pA70