Comparison of neuronal and hemodynamic measures of the brain response to visual stimulation: An optical imaging study

被引:86
作者
Gratton, G [1 ]
Goodman-Wood, MR [1 ]
Fabiani, M [1 ]
机构
[1] Univ Missouri, Dept Psychol Sci, Columbia, MO 65211 USA
关键词
event-related optical signal (EROS); near-infrared spectroscopy (NIRS); neuronal measures; hemodynamic measures; neurovascular coupling;
D O I
10.1002/hbm.1021
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The noninvasive mapping of hemodynamic brain activity has led to significant advances in neuroimaging. This approach is based in part on the assumption that hemodynamic changes are proportional to (and therefore constitute a linear measure of) neuronal activity. We report a study investigating the quantitative relationship between neuronal and hemodynamic measures. This study exploited the fact that optical imaging methods can simultaneously provide noninvasive measures of neuronal and hemodynamic activity from the same region of the brain. We manipulated Visual stimulation frequency and measured responses from the medial occipital area of 8 young adults. The results were consistent with a model postulating a linear relationship between the neuronal activity integrated over time and the amplitude of the hemodynamic response. The hemodynamic response colocalized with the neuronal response. These data support the use of quantitative neuroimaging methods to infer the intensity and localization of neuronal activity in occipital areas. Hum. Brain Mapping 13:13-25, 2001. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:13 / 25
页数:13
相关论文
共 51 条
[31]   HUMAN VISUAL CORTICAL FUNCTION DURING PHOTIC-STIMULATION MONITORING BY MEANS OF NEAR-INFRARED SPECTROSCOPY [J].
KATO, T ;
KAMEI, A ;
TAKASHIMA, S ;
OZAKI, T .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (03) :516-520
[32]   DYNAMIC MAGNETIC-RESONANCE-IMAGING OF HUMAN BRAIN ACTIVITY DURING PRIMARY SENSORY STIMULATION [J].
KWONG, KK ;
BELLIVEAU, JW ;
CHESLER, DA ;
GOLDBERG, IE ;
WEISSKOFF, RM ;
PONCELET, BP ;
KENNEDY, DN ;
HOPPEL, BE ;
COHEN, MS ;
TURNER, R ;
CHENG, HM ;
BRADY, TJ ;
ROSEN, BR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5675-5679
[33]   PRINCIPAL COMPONENTS-ANALYSIS FOR SOURCE LOCALIZATION OF VEPS IN MAN [J].
MAIER, J ;
DAGNELIE, G ;
SPEKREIJSE, H ;
VANDIJK, BW .
VISION RESEARCH, 1987, 27 (02) :165-177
[34]   Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: Implications for functional brain mapping [J].
Malonek, D ;
Grinvald, A .
SCIENCE, 1996, 272 (5261) :551-554
[35]   Involvement of striate and extrastriate visual cortical areas in spatial attention [J].
Martínez, A ;
Anllo-Vento, L ;
Sereno, MI ;
Frank, LR ;
Buxton, RB ;
Dubowitz, DJ ;
Wong, EC ;
Hinrichs, H ;
Heinze, HJ ;
Hillyard, SA .
NATURE NEUROSCIENCE, 1999, 2 (04) :364-369
[36]   Cerebral vasomotion: A 0.1-Hz oscillation in reflected light imaging of neural activity [J].
Mayhew, JEW ;
Askew, S ;
Zheng, Y ;
Porrill, J ;
Westby, GWM ;
Redgrave, P ;
Rector, DM ;
Harper, RM .
NEUROIMAGE, 1996, 4 (03) :183-193
[37]   INTRINSIC SIGNAL CHANGES ACCOMPANYING SENSORY STIMULATION - FUNCTIONAL BRAIN MAPPING WITH MAGNETIC-RESONANCE-IMAGING [J].
OGAWA, S ;
TANK, DW ;
MENON, R ;
ELLERMANN, JM ;
KIM, SG ;
MERKLE, H ;
UGURBIL, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :5951-5955
[38]   Theoretical and experimental investigation of near-infrared light propagation in a model of the adult head [J].
Okada, E ;
Firbank, M ;
Schweiger, M ;
Arridge, SR ;
Cope, M ;
Delpy, DT .
APPLIED OPTICS, 1997, 36 (01) :21-31
[39]  
Papillo JF., 1990, PRINCIPLES PSYCHOPHY, P456
[40]   LOW-RESOLUTION ELECTROMAGNETIC TOMOGRAPHY - A NEW METHOD FOR LOCALIZING ELECTRICAL-ACTIVITY IN THE BRAIN [J].
PASCUALMARQUI, RD ;
MICHEL, CM ;
LEHMANN, D .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 1994, 18 (01) :49-65