Molecular characterization of the Aedes aegypti odorant receptor gene family

被引：173

作者：

Bohbot, J.

Pitts, R. J.

Kwon, H.-W.

Ruetzler, M.

Robertson, H. M.

Zwiebel, L. J.

机构：

[1] Vanderbilt Univ, Inst Global Hlth, Ctr Chem Biol, Program Dev Biol & Genet,Dept Biol Sci, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Inst Global Hlth, Ctr Mol Neurosci, Program Dev Biol & Genet,Dept Biol Sci, Nashville, TN 37235 USA

[3] Univ Illinois, Dept Entomol, Urbana, IL 61801 USA

来源：

INSECT MOLECULAR BIOLOGY | 2007年 / 16卷 / 05期

关键词：

odourant receptor; olfaction; genome; Aedes aegypti; Anopheles gambiae;

D O I：

10.1111/j.1365-2583.2007.00748.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The olfactory-driven blood-feeding behaviour of female Aedes aegypti mosquitoes is the primary transmission mechanism by which the arboviruses causing dengue and yellow fevers affect over 40 million individuals worldwide. Bioinformatics analysis has been used to identify 131 putative odourant receptors from the A. aegypti genome that are likely to function in chemosensory perception in this mosquito. Comparison with the Anopheles gambiae olfactory subgenome demonstrates significant divergence of the odourant receptors that reflects a high degree of evolutionary activity potentially resulting from their critical roles during the mosquito life cycle. Expression analyses in the larval and adult olfactory chemosensory organs reveal that the ratio of odourant receptors to antennal glomeruli is not necessarily one to one in mosquitoes.

引用

页码：525 / 537

页数：13

共 63 条

[11]

Ejima A, 2007, CURR BIOL, V17, P599, DOI 10.1016/j.cub.2007.01.053

[12] Genetic and functional subdivision of the Drosophila antennal lobe [J].

Fishilevich, E ;

Vosshall, LB .

CURRENT BIOLOGY, 2005, 15 (17) :1548-1553

[13] Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding [J].

Fox, AN ;

Pitts, RJ ;

Robertson, HM ;

Carlson, JR ;

Zwiebel, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14693-14697

[14] A digital three-dimensional atlas of the honeybee antennal lobe based on optical sections acquired by confocal microscopy [J].

Galizia, CG ;

McIlwrath, SL ;

Menzel, R .

CELL AND TISSUE RESEARCH, 1999, 295 (03) :383-394

[15] Identification of candidate Drosophila olfactory receptors from genomic DNA sequence [J].

Gao, Q ;

Chess, A .

GENOMICS, 1999, 60 (01) :31-39

[16] The repertoire of trace amine G-protein-coupled receptors:: large expansion in zebrafish [J].

Gloriam, DEI ;

Bjarnadóttir, TK ;

Yan, YL ;

Postlethwait, JH ;

Schiöth, HB ;

Fredriksson, R .

MOLECULAR PHYLOGENETICS AND EVOLUTION, 2005, 35 (02) :470-482

[17] Coexpression of two functional odor receptors in one neuron [J].

Goldman, AL ;

van Naters, WV ;

Lessing, D ;

Warr, CG ;

Carlson, JR .

NEURON, 2005, 45 (05) :661-666

[18]

GRANT AJ, 1995, J COMP PHYSIOL A, V177, P389, DOI 10.1007/BF00187475

[19] Insect odor and taste receptors [J].

Hallem, EA ;

Dahanukar, A ;

Carlson, JR .

ANNUAL REVIEW OF ENTOMOLOGY, 2006, 51 :113-135

[20] The molecular basis of odor coding in the drosophila antenna [J].

Hallem, EA ;

Ho, MG ;

Carlson, JR .

CELL, 2004, 117 (07) :965-979

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