Characterization of drugs as antioxidant prophylactics

被引：145

作者：

Aruoma, OI

机构：

[1] Pharmacology Group, University of London King's College, London

[2] Pharmacology Group, University of London King's College, London SW3 6LX, Manresa Road

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1996年 / 20卷 / 05期

关键词：

free radicals; oxidative stress; human diseases; antioxidants; drug design;

D O I：

10.1016/0891-5849(95)02110-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is growing interest in the evaluation of drugs (prescription only medicines and over-the-counter medicines) as antioxidant prophylactics. Although free radical mechanism in human degenerative diseases is now generally recognised, the mechanisms of tissue injury in humans are very complex and it may not be possible to clearly identify the role played by free radicals in the process. This review examines the current evidence to support the notion that drugs for a particular therapeutic category might possess useful antioxidant capacity hence minimising tissue injury due to free radicals.

引用

页码：675 / 705

页数：31

共 472 条

[21] A SENSITIVE FLUOROMETRIC ASSAY FOR PROTEIN-BOUND DOPA AND RELATED PRODUCTS OF RADICAL-MEDIATED PROTEIN OXIDATION [J].