Electroacupuncture improves cognitive deficits associated with AMPK activation in SAMP8 mice

被引：46

作者：

Dong, Weiguo ^{[1
]}

Guo, Wanqing ^{[2
]}

Zheng, Xuehua ^{[1
]}

Wang, Feng ^{[1
]}

Chen, Yue ^{[1
]}

Zhang, Wenguang ^{[1
]}

Shi, Hong ^{[1
]}

机构：

[1] Fujian Univ Tradit Chinese Med, Dept Integrated Tradit Chinese & Western Med, Fuzhou 350122, Fujian, Peoples R China

[2] Third Peoples Hosp Fujian Prov, Fuzhou 350122, Fujian, Peoples R China

来源：

METABOLIC BRAIN DISEASE | 2015年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; Electroacupuncture; Adenosine monophosphate-activated kinase; Memory; ALZHEIMERS-DISEASE; PROTEIN-KINASE; METABOLIC-CONTROL; ACUPUNCTURE; BRAIN; IMPAIRMENT; NEURONS; RATS; PRETREATMENT; HIPPOCAMPUS;

D O I：

10.1007/s11011-014-9641-1

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Perturbations of brain energy metabolism are involved in Alzheimer's disease (AD). Adenosine monophosphate-activated kinase (AMPK) is a master energy sensor that monitors the levels of key energy metabolites. Electroacupuncture (EA) has demonstrated therapeutic potential for the treatment of AD. The effects of EA on cognitive functions and the changes of AMPK and its phosphorylated form (p-AMPK) expression were investigated in senescence-accelerated mouse prone 8 (SAMP8) mice. Cognitive function of SAMP8 mice was assessed using Morris water maze test after EA treatment. Then mice were sacrificed for immunohistochemistry and western blot analysis. EA stimulation significantly alleviated memory impairment of AD mice, and increased the levels of p-AMPK in the hippocampus. These results suggest that EA improved cognitive function associated with AMPK activation, AMPK may be a molecular target of EA in treating AD.

引用

页码：777 / 784

页数：8

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