On the origin of residual dipolar couplings from denatured proteins

被引：93

作者：

Louhivuori, M

Pääkkönen, K

Fredriksson, K

Permi, P

Lounila, J

Annila, A ^{[1
]}

机构：

[1] Univ Helsinki, Inst Biotechnol, Helsinki, Finland

[2] Univ Helsinki, Dept Phys Sci, Helsinki, Finland

[3] VTT Biotechnol, Espoo, Finland

[4] Univ Helsinki, Dept Biosci, Helsinki, Finland

[5] Univ Oulu, Dept Phys Sci, Oulu, Finland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 50期

关键词：

D O I：

10.1021/ja035427v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Effects of steric obstruction on random flight chains are examined. Spatial probability distributions are elaborated to calculate residual dipolar couplings and residual chemical shift anisotropy, parameters that are acquired by NMR spectroscopy from solutes dissolved in dilute liquid crystals. Calculations yield chain length and residue position-dependent values in good agreement with simulations to provide understanding of recently acquired data from denatured proteins.

引用

收藏

页码：15647 / 15650

页数：4

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