Substrate specificity:: PI(3)Kγ has it both ways

被引：5

作者：

Backer, JM ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 08期

关键词：

D O I：

10.1038/ncb0805-773

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)K gamma. Phosphorylation of tropomyosin is required for beta-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.

引用

页码：773 / 774

页数：2

共 16 条

[1] Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin
Blanchoin, L
Pollard, TD
Hitchcock-DeGregori, SE
[J]. CURRENT BIOLOGY, 2001, 11 (16) : 1300 - 1304
[2] Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK
Bondeva, T
Pirola, L
Bulgarelli-Leva, G
Rubio, I
Wetzker, R
Wymann, MP
[J]. SCIENCE, 1998, 282 (5387) : 293 - 296
[3] Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ
Czupalla, C
Culo, M
Müller, EC
Brock, C
Reusch, HP
Spicher, K
Krause, E
Nürnberg, B
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) : 11536 - 11545
[4] Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge
DesMarais, V
Ichetovkin, I
Condeelis, J
Hitchcock-DeGregori, SE
[J]. JOURNAL OF CELL SCIENCE, 2002, 115 (23) : 4649 - 4660
[5] PI-3-KINASE IS A DUAL-SPECIFICITY ENZYME - AUTOREGULATION BY AN INTRINSIC PROTEIN-SERINE KINASE-ACTIVITY
DHAND, R
HILES, I
PANAYOTOU, G
ROCHE, S
FRY, MJ
GOUT, I
TOTTY, NF
TRUONG, O
VICENDO, P
YONEZAWA, K
KASUGA, M
COURTNEIDGE, SA
WATERFIELD, MD
[J]. EMBO JOURNAL, 1994, 13 (03) : 522 - 533
[6] Actin assembly and endocytosis:: From yeast to mammals
Engqvist-Goldstein, ÅEY
Drubin, DG
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2003, 19 : 287 - 332
[7] Tropomyosin isoforms: divining rods for actin cytoskeleton function
Gunning, PW
Schevzov, G
Kee, AJ
Hardeman, EC
[J]. TRENDS IN CELL BIOLOGY, 2005, 15 (06) : 333 - 341
[8] Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function
Laffargue, M
Calvez, R
Finan, P
Trifilieff, A
Barbier, M
Altruda, F
Hirsch, E
Wymann, MP
[J]. IMMUNITY, 2002, 16 (03) : 441 - 451
[9] LAM K, 1994, J BIOL CHEM, V269, P20648
[10] Vertebrate tropomyosin: distribution, properties and function
Perry, SV
[J]. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2001, 22 (01) : 5 - 49

← 1 2 →