Substrate specificity:: PI(3)Kγ has it both ways

被引：5

作者：

Backer, JM ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 08期

关键词：

D O I：

10.1038/ncb0805-773

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)K gamma. Phosphorylation of tropomyosin is required for beta-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.

引用

页码：773 / 774

页数：2

共 16 条

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