Human regulatory T cells and autoimmunity

被引：114

作者：

Costantino, Cristina M.

Baecher-Allan, Clare M.

Hafler, David A. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Div Mol Immunol, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Autoimmunity; Human; Regulatory T cell;

D O I：

10.1002/eji.200738104

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+)CD25(+) regulatory T cells (Treg) appear to be critical in regulating immune responses to self-antigens. Treg deficiency is associated with several human autoimmune diseases. Although substantial progress has been made in the study of murine and human Treg, their fundamental mechanism of action remains unknown. In this review, we discuss the phenotype of human natural Treg, their functional mechanism, and their role in autoimmune disease.

引用

页码：921 / 924

页数：4

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