Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments

被引：151

作者：

Baj, Gabriele ^{[1
]}

Leone, Emiliano ^{[1
]}

Chao, Moses V. ^{[2
,3
,4
]}

Tongiorgi, Enrico ^{[1
]}

机构：

[1] Univ Trieste, Dept Life Sci, BRAIN Ctr Neurosci, I-34127 Trieste, Italy

[2] NYU, Sch Med, Skirball Inst, Dept Cell Biol, New York, NY 10016 USA

[3] NYU, Sch Med, Skirball Inst, Dept Physiol & Neurosci, New York, NY 10016 USA

[4] NYU, Sch Med, Skirball Inst, Dept Psychiat, New York, NY 10016 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2011年 / 108卷 / 40期

基金：

美国国家卫生研究院;

关键词：

development; neurotrophins; plasticity; MESSENGER-RNA; NEUROTROPHIC FACTOR; HIPPOCAMPAL-NEURONS; SUBCELLULAR-LOCALIZATION; SYNAPTIC PLASTICITY; SIGNALING PATHWAYS; TOTAL NUMBER; RAT-BRAIN; IN-VIVO; EXPRESSION;

D O I：

10.1073/pnas.1014168108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

BDNF is produced from many transcripts that display distinct subcellular localization, suggesting that spatially restricted effects occur as a function of genetic and physiological regulation. Different BDNF 5' splice variants give a restricted localization in the cell body or the proximal and distal compartments of dendrites; however, the functional consequences are not known. Silencing individual endogenous transcripts or overexpressing BDNF-GFP transcripts in cultured neurons demonstrated that whereas some transcripts (1 and 4) selectively affected proximal dendrites, others (2C and 6) affected distal dendrites. Moreover, segregation of BDNF transcripts resulted in a highly selective activation of the BDNF TrkB receptor. These studies indicate that spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments.

引用

页码：16813 / 16818

页数：6

共 45 条

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Difference in trafficking of brain-derived neurotrophic factor between axons and dendrites of cortical neurons, revealed by live-cell imaging [J].