Electrochemical monitoring of single cell secretion:: Vesicular exocytosis and oxidative stress

Several important contributions of electroanalytical techniques over the past 20 years for investigating three major biological processes at the single cell level: vesicular exocytosis, oxidative stress, and nitric oxide metabolism in brain have been reported. It is evident that molecular electrochemistry at microelectrodes enhances the understanding of central processes of cellular biology including cellular metabolism either at a single cell stage or in living tissues. Since cells have highly variable metabolism even among single genetic lines, studies performed at the single cell level allow delineating precisely the extent and limits of these variabilities.