Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii, Including Multidrug-Resistant Isolates, from New York City

被引：114

作者：

Abdallah, Marie ^{[1
]}

Olafisoye, Olawole ^{[1
]}

Cortes, Christopher ^{[2
]}

Urban, Carl ^{[2
]}

Landman, David ^{[1
]}

Quale, John ^{[1
]}

机构：

[1] Suny Downstate Med Ctr, Div Infect Dis, Brooklyn, NY 11203 USA

[2] New York Hosp Queens, Dr James J Rahal Jr Div Infect Dis, Flushing, NY USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 03期

关键词：

ANTIMICROBIAL RESISTANCE; FLUOROCYCLINE; PATHOGENS; SAFETY; TP-434;

D O I：

10.1128/AAC.04809-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 mu g/ml, Klebsiella pneumoniae of 0.25/1 mu g/ml, Enterobacter aerogenes of 0.25/1 mu g/ml, Enterobacter cloacae 0.5/1 mu g/ml, and Acinetobacter baumannii of 0.5/1 mu g/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene.

引用

页码：1802 / 1805

页数：4

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