Colistin pharmacokinetics: the fog is lifting

被引：99

作者：

Couet, W. ^{[1
]}

Gregoire, N. ^{[1
]}

Marchand, S. ^{[1
]}

Mimoz, O. ^{[1
,2
]}

机构：

[1] Univ Poitiers, UFR Med Pharm, Serv Toxicol & Pharmacocinet, CHU,INSERM ERI 23, F-86022 Poitiers, France

[2] Univ Hosp Poitiers, Intens Care Unit, Poitiers, France

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷 / 01期

关键词：

Colistin; critical-care patients; pharmacokinetics; prodrug; simulations; CRITICALLY-ILL PATIENTS; PERFORMANCE LIQUID-CHROMATOGRAPHY; MULTIDRUG-RESISTANT; METHANESULFONATE; INFECTIONS; RATS; PLASMA; BACTERIA; THERAPY; SODIUM;

D O I：

10.1111/j.1469-0691.2011.03667.x

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Colistin is a re-emerging old antibiotic that is used to treat multidrug-resistant infections in critically ill patients. It corresponds to a mixture of at least 30 different compounds administered as inactive derivatives. Therefore, colistin pharmacokinetics are quite difficult to investigate and complex to predict. However specific chromatographic methods have been made available in recent years, leading to a series of modern pharmacokinetic studies after intravenous administration of the prodrug to critical-care patients; these have been conducted by a few groups and have only been recently published. The objective of this article was to conduct a critical review of these very informative modern pharmacokinetic studies and to provide prospective thoughts.

引用

收藏

页码：30 / 39

页数：10

相关论文

共 22 条

[1]

[Anonymous], 2010, Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications

[2]

Pharmacokinetics of Colistin and Colistimethate Sodium After a Single 80-mg Intravenous Dose of CMS in Young Healthy Volunteers [J].

Couet, W. ;

Gregoire, N. ;

Gobin, P. ;

Saulnier, P. J. ;

Frasca, D. ;

Marchand, S. ;

Mimoz, O. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 (06) :875-879

[3]

Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients [J].

Garonzik, S. M. ;

Li, J. ;

Thamlikitkul, V. ;

Paterson, D. L. ;

Shoham, S. ;

Jacob, J. ;

Silveira, F. P. ;

Forrest, A. ;

Nation, R. L. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (07) :3284-3294

[4]

Assay of Colistin and Colistin Methanesulfonate in Plasma and Urine by Liquid Chromatography-Tandem Mass Spectrometry [J].

Gobin, Patrice ;

Lemaitre, Florian ;

Marchand, Sandrine ;

Couet, William ;

Olivier, Jean-Christophe .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) :1941-1948

[5]

Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS [J].

Jansson, Britt ;

Karvanen, Matti ;

Cars, Otto ;

Plachouras, Diamantis ;

Friberg, Lena E. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, 49 (03) :760-767

[6]

Pharmacokinetics of colistin methanesulfonate and colistin in a critically ill patient receiving continuous venovenous hemodiafiltration [J].

Li, J ;

Rayner, CR ;

Nation, RL ;

Deans, R ;

Boots, R ;

Widdecombe, N ;

Douglas, A ;

Lipman, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (11) :4814-4815

[7]

Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate [J].

Li, J ;

Milne, RW ;

Nation, RL ;

Turnidge, JD ;

Smeaton, TC ;

Coulthard, K .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (05) :837-840

[8]

Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis [J].

Li, J ;

Coulthard, K ;

Milne, R ;

Nation, RL ;

Conway, S ;

Peckham, D ;

Etherington, C ;

Turnidge, J .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (06) :987-992

[9]

Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration [J].

Li, J ;

Milne, RW ;

Nation, RL ;

Turnidge, JD ;

Smeaton, TC ;

Coulthard, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (05) :1766-1770

[10]

Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography [J].

Li, J ;

Milne, RW ;

Nation, RL ;

Turnidge, JD ;

Coulthard, K ;

Valentine, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (10) :3304-3307