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The prospect of silencing disease using RNA interference

被引：106
作者：
Shankar, P
Manjunath, N
Lieberman, J
机构：
[1] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
来源：
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2005年 / 293卷 / 11期
关键词：
D O I：
10.1001/jama.293.11.1367
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therapeutic applications. In this article we discuss the basic mechanism of RNA! and the therapeutic opportunities and obstacles for harnessing RNAi for therapy of human disease.
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页码：1367 / 1373
页数：7
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