Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery

被引：66

作者：

Lukyanov, AN ^{[1
]}

Gao, ZG ^{[1
]}

Torchilin, VP ^{[1
]}

机构：

[1] Northeastern Univ, Bouve Coll Hlth Sci, Dept Pharmaceut Sci, Boston, MA 02115 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2003年 / 91卷 / 1-2期

关键词：

PEG-lipid conjugates; polymeric micelles; anticancer antibody; immunomicelles; tumor targeting;

D O I：

10.1016/S0168-3659(03)00217-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Micelles prepared from polyethylene glycols of various lengths conjugated with phosphatidylethanolamine (PEG-PE) were loaded with various poorly soluble anticancer agents. PEG-PE micelles selectively accumulated in Lewis lung carcinoma (LLC) tumors implanted in mice. Modification of the micelles with tumor specific antibodies further enhanced the efficiency of tumor accumulation. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：97 / 102

页数：6

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