Affinity of a vancomycin polymer with bacterial surface models

被引：16

作者：

Arimoto, H

Oishi, T

Nishijima, M

Kinumi, T

机构：

[1] Shizuoka Univ, Fac Sci, Dept Chem, Shizuoka 4228529, Japan

[2] Natl Inst Infect Dis, Dept Biochem & Cell Biol, Tokyo 1628640, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(01)00429-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The affinity between a vancomycin polymer (3) and cell wall intermediate mimics of vancomycin resistant bacteria (VRE) was determined by use of surface plasmon resonance (SPR). The increased affinity of 3 over monomeric vancomycin derivatives 1 and 2 suggests the importance of tighter binding to VRE surfaces in the enhanced antibacterial activities of 3. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3347 / 3350

页数：4

共 11 条

[1] Multi-valent polymer of vancomycin: enhanced antibacterial activity against VRE [J].