9-cis Retinoic acid induces the expression of the uncoupling protein-2 gene in brown adipocytes

被引：27

作者：

Carmona, MC ^{[1
]}

Valmaseda, A ^{[1
]}

Iglesias, R ^{[1
]}

Mampel, T ^{[1
]}

Viñas, O ^{[1
]}

Giralt, M ^{[1
]}

Villarroya, F ^{[1
]}

机构：

[1] Univ Barcelona, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

FEBS LETTERS | 1998年 / 441卷 / 03期

关键词：

brown adipose tissue; uncoupling protein-2; uncoupling protein-1; 9-cis retinoic acid; thermogenesis;

D O I：

10.1016/S0014-5793(98)01598-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of uncoupling protein-2 (UCP2) mRNA is up-regulated during the differentiation of brown adipocytes in primary culture. When differentiation of brown adipocytes is impaired, UCP2 mRNA expression is down-regulated, 9-cis Retinoic acid causes a dose-dependent induction of UCP2 mRNA levels in brown adipocytes, whereas all-trans retinoic acid has no effect. Specific agonists of retinoid X receptors (RXR) induce UCP2 mRNA expression, whereas specific activators of retinoic acid receptors do not. 9-cis Retinoic acid, acting through RXR receptors, is identified as a major regulator of the expression of the UCP2 gene in the brown fat cell. (C) 1998 Federation of European Biochemical Societies.

引用

页码：447 / 450

页数：4

共 36 条

[31]

Teruel T, 1998, J CELL PHYSIOL, V176, P99, DOI 10.1002/(SICI)1097-4652(199807)176:1<99::AID-JCP12>3.0.CO

[32]

2-J

[33] UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue [J].

VidalPuig, A ;

Solanes, G ;

Grujic, D ;

Flier, JS ;

Lowell, BB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (01) :79-82

[34] Differential effects of retinoic acid on white and brown adipose tissues - An unexpected role for vitamin A derivatives on energy balance [J].

Villarroya, F .

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY: FROM MOLECULAR TO INTEGRATIVE BIOLOGY, 1998, 839 :190-195

[35] Regulation of mitochondrial biogenesis in brown adipose tissue:: nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase β subunit [J].

Villena, JA ;

Viñas, O ;

Mampel, T ;

Iglesias, R ;

Giralt, M ;

Villarroya, F .

BIOCHEMICAL JOURNAL, 1998, 331 :121-127

[36]

ZHOU YT, 1997, P NATL ACAD SCI USA, V94, P6389

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