The impact of aging on cancer vaccination

被引：14

作者：

Gravekamp, Claudia ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 04期

关键词：

NATURAL-KILLER-CELLS; REGULATORY T-CELLS; ALPHA-GALACTOSYLCERAMIDE; DENDRITIC CELLS; SUPPRESSOR-CELLS; IMMUNE MEMORY; NKT CELLS; ANTITUMOR; AGE; MICE;

D O I：

10.1016/j.coi.2011.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer vaccination is less effective at old than at young age, due to T cell unresponsiveness, caused by various age-related changes of the immune system. This includes lack of naive T cells, defects in activation pathways of T cells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment. Although evidence exists that also natural killer (NK) and natural killer T (NKT) cells of the innate immune system change with age, comparison of various studies involving adaptive and innate immune responses in elderly and cancer patients, as well as cancer vaccination at young and old age in this review, indicates that also innate immune responses should be tested as a potential candidate to improve immunotherapy against cancer at older age.

引用

页码：555 / 560

页数：6

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