Efficient preparation of 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl chloride

被引：9

作者：

Dhimitruka, I ^{[1
]}

SantaLucia, J ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

SYNLETT | 2004年 / 02期

关键词：

1-O-methyl-3,5-di-O-p-toluoyl-2-deoxy-alpha/beta-D-ribose; 2-deoxy-3,5-di-O-p-toluoyl-alpha-D-ribofuranosyl chloride; 1-O-methyl-2-deoxy-alpha/beta-D-ribose; hydrogen chloride; p-toluic anhydride;

D O I：

10.1055/s-2003-45000

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of 1-O-methyl-3,5-di-O-p-toluoyl-2-deoxy-alpha/beta-D-ribose is described. Upon treatment with HCl, 2-deoxy-3,5-di-O-p-toluoyl-alphaw-D-ribofuranosyl chloride, previously unstable, was produced as a white solid, stable in air indefinitely.

引用

页码：335 / 337

页数：3

共 11 条

[1]

Bailly C, 2001, METHOD ENZYMOL, V340, P485

[2]

Cherkasova E. M., 1977, RUSS CHEM REV, V46, P246, DOI 10.1070/RC1977V046N03ABEH002130

[3] Improved syntheses of halofuranose derivatives with the desired alpha-configuration [J].