The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis

被引：73

作者：

Ohashi, Y

Chijiiwa, Y

Suzuki, K

Takahashi, K

Nanamiya, H

Sato, T

Hosoya, Y

Ochi, K

Kawamura, F

机构：

[1] Rikkyo Univ, Coll Sci, Genet Mol Lab, Toshima Ku, Tokyo 1718501, Japan

[2] Tokyo Univ Agr & Technol, Dept Appl Biol Sci, Fuchu, Tokyo 1830054, Japan

[3] Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 04期

关键词：

D O I：

10.1128/JB.181.4.1348-1351.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.

引用

收藏

页码：1348 / 1351

页数：4

相关论文

共 29 条

[1] CLONING AND CHARACTERIZATION OF BACILLUS-SUBTILIS HOMOLOGS OF ESCHERICHIA-COLI CELL-DIVISION GENE-FTSZ AND GENE-FTSA [J].

BEALL, B ;

LOWE, M ;

LUTKENHAUS, J .

JOURNAL OF BACTERIOLOGY, 1988, 170 (10) :4855-4864

[2] FTSZ IN BACILLUS-SUBTILIS IS REQUIRED FOR VEGETATIVE SEPTATION AND FOR ASYMMETRIC SEPTATION DURING SPORULATION [J].

BEALL, B ;

LUTKENHAUS, J .

GENES & DEVELOPMENT, 1991, 5 (03) :447-455

[3] FTSZ RING STRUCTURE ASSOCIATED WITH DIVISION IN ESCHERICHIA-COLI [J].

BI, E ;

LUTKENHAUS, J .

NATURE, 1991, 354 (6349) :161-164

[4] GTP-DEPENDENT POLYMERIZATION OF ESCHERICHIA-COLI FTSZ PROTEIN TO FORM TUBULES [J].

BRAMHILL, D ;

THOMPSON, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5813-5817

[5] THE ESSENTIAL BACTERIAL CELL-DIVISION PROTEIN FTSZ IS A GTPASE [J].

DEBOER, P ;

CROSSLEY, R ;

ROTHFIELD, L .

NATURE, 1992, 359 (6392) :254-256

[6] Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers [J].

Erickson, HP ;

Taylor, DW ;

Taylor, KA ;

Bramhill, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :519-523

[7] FtsZ, a tubulin homologue in prokaryote cell division [J].

Erickson, HP .

TRENDS IN CELL BIOLOGY, 1997, 7 (09) :362-367

[8] ADP-ribosylation of proteins in Bacillus subtilis and its possible importance in sporulation [J].

Huh, JW ;

Shima, J ;

Ochi, K .

JOURNAL OF BACTERIOLOGY, 1996, 178 (16) :4935-4941

[9] THE BACILLUS-SUBTILIS SPOIIG OPERON ENCODES BOTH SIGMA-E AND A GENE NECESSARY FOR SIGMA-E ACTIVATION [J].

JONAS, RM ;

WEAVER, EA ;

KENNEY, TJ ;

MORAN, CP ;

HALDENWANG, WG .

JOURNAL OF BACTERIOLOGY, 1988, 170 (02) :507-511

[10] The complete genome sequence of the Gram-positive bacterium Bacillus subtilis [J].

Kunst, F ;

Ogasawara, N ;

Moszer, I ;

Albertini, AM ;

Alloni, G ;

Azevedo, V ;

Bertero, MG ;

Bessieres, P ;

Bolotin, A ;

Borchert, S ;

Borriss, R ;

Boursier, L ;

Brans, A ;

Braun, M ;

Brignell, SC ;

Bron, S ;

Brouillet, S ;

Bruschi, CV ;

Caldwell, B ;

Capuano, V ;

Carter, NM ;

Choi, SK ;

Codani, JJ ;

Connerton, IF ;

Cummings, NJ ;

Daniel, RA ;

Denizot, F ;

Devine, KM ;

Dusterhoft, A ;

Ehrlich, SD ;

Emmerson, PT ;

Entian, KD ;

Errington, J ;

Fabret, C ;

Ferrari, E ;

Foulger, D ;

Fritz, C ;

Fujita, M ;

Fujita, Y ;

Fuma, S ;

Galizzi, A ;

Galleron, N ;

Ghim, SY ;

Glaser, P ;

Goffeau, A ;

Golightly, EJ ;

Grandi, G ;

Guiseppi, G ;

Guy, BJ ;

Haga, K .

NATURE, 1997, 390 (6657) :249-256