An improved surface plasmon resonance imaging apparatus

被引：35

作者：

Lyon, LA ^{[1
]}

Holliway, WD ^{[1
]}

Natan, MJ ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

REVIEW OF SCIENTIFIC INSTRUMENTS | 1999年 / 70卷 / 04期

关键词：

D O I：

10.1063/1.1149716

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The design, construction, and initial use of an improved surface plasmon resonance imaging instrument are described. The instrument construction allows for introduction of large samples (50x50 mm) and is arranged with a unique horizontal sample geometry. This horizontal geometry provides for the eventual introduction of standard robotics both for substrate handling and liquid delivery, as with other commercialized analytical imaging techniques. The versatile optical train makes the instrument ideal for a wide range of sample sizes and provides for variable lateral resolution. Very small variations in colloidal Au coverage are detected on a patterned substrate, thereby demonstrating the utility of colloidal Au as a surface plasmon resonance imaging contrast reagent. (C) 1999 American Institute of Physics. [S0034-6748(99)01903-6].

引用

页码：2076 / 2081

页数：6

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