Oxidative stress, aging and longevity in Drosophila melanogaster

被引：84

作者：

Le Bourg, É ^{[1
]}

机构：

[1] Univ Toulouse 3, ERS CNRS 2382, Lab Ethol & Cognit Anim, F-31062 Toulouse 4, France

来源：

FEBS LETTERS | 2001年 / 498卷 / 2-3期

关键词：

free radical theory of aging; antioxidant enzyme; antioxidant compound; aging; longevity; Drosophila melanogaster;

D O I：

10.1016/S0014-5793(01)02457-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free radicals produced during normal metabolism cause damage to macromolecules. The free radical theory of aging proposes that the organism is unable to repair all of them and that, with time, unrepaired damages accumulate and put the organism at risk: in other words, free radicals provoke aging and death. This article reviews both the results of adding antioxidants to food on longevity in Drosophila melanogaster, as well as the studies on antioxidant enzymes (inactivation in vivo, null mutants, overexpression). It is concluded that antioxidant enzymes are probably poorly connected to the normal aging process, but they allow the organism to cope with stressful conditions. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：183 / 186

页数：4

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