Chemical modification of manganese porphyrins with biomolecules for new functional antioxidants

被引:16
作者
Asayama, S [1 ]
Mori, T [1 ]
Nagaoka, S [1 ]
Kawakami, H [1 ]
机构
[1] Tokyo Metropolitan Univ, Dept Appl Chem, Tokyo 1920397, Japan
关键词
manganese porphyrin; SOD mimic; carbohydrate; catalase; active targeting; antioxidant; bioconjugate;
D O I
10.1163/156856203322553419
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Superoxide dismutase (SOD), which catalyzes the reduction of O-2(.-) to H2O2, is the key enzyme for the protection of oxidative stress. Here we have chemically modified manganese (Mn) porphyrins with biomolecules for new functional antioxidants. The Mn-porphyrins were conjugated with the following biochemical functional molecules: (1) catalase, to catalyze reduction of H2O2 to H2O. The resulting conjugate showed dual functions of SOD and catalase; (2) a carbohydrate, to facilitate receptor binding and, hence, active targeting. The resulting conjugate showed both SOD activity and carbohydrate recognition. These results suggest that the antioxidants promise the application to biomedical fields.
引用
收藏
页码:1169 / 1179
页数:11
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