Ceramic capillaries for use in microarray fabrication

被引：15

作者：

George, RA ^{[1
]}

Woolley, JP ^{[1
]}

Spellman, PT ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, BDGP, Berkeley, CA 94720 USA

来源：

GENOME RESEARCH | 2001年 / 11卷 / 10期

关键词：

D O I：

10.1101/gr.190801

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have used ceramic capillary tips generally used in the microelectronics industry for the production of DNA microarrays. The ceramic tips improve the morphology of microarray elements, allow higher element density, and increase printing tip life over the customary slotted stainless-steel pins. Ceramic tips are less expensive than steel pins and allow printing from 1536-well sample source plates. In this work, we describe experiments that establish printing performance of the ceramic tips and hybridization experiments that show that DNA hybridization is unaffected by the choice of tip material.

引用

页码：1780 / 1783

页数：4

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