Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes

被引：71

作者：

Hernández-Allés, S

Benedí, VJ

Martínez-Martínez, L

Pascual, A

Aguilar, A

Tomás, JM

Albertí, S

机构：

[1] Univ Balearic Isl, Area Microbiol, Dept Biol, E-07071 Palma de Mallorca, Spain

[2] IMEDEA, UIB, CSIC, Palma de Mallorca, Spain

[3] Univ Sevilla, Dept Microbiol, Seville, Spain

[4] Univ Barcelona, Dept Microbiol, Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 04期

关键词：

D O I：

10.1128/AAC.43.4.937

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes toss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.

引用

页码：937 / 939

页数：3

共 20 条

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