Update on genetic disorders affecting white matter

被引：67

作者：

Kaye, EM ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Sect Biochem Genet, Philadelphia, PA 19104 USA

来源：

PEDIATRIC NEUROLOGY | 2001年 / 24卷 / 01期

关键词：

D O I：

10.1016/S0887-8994(00)00232-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The classification of diseases affecting white matter has changed dramatically with the use of magnetic resonance imaging. Classical leukodystrophies, such as metachromatic leukodystrophy and Krabbe's disease, account for only a small number of inherited diseases that affect white matter. Magnetic resonance imaging has clarified genetic disorders that result in white matter changes or leukoencephalopathies. The term leukoencephalopathy is used to reflect the broader number of diseases that may cause as either primary or secondary changes in myelin development. This review attempts to categorize white matter disorders into classes such as lipid, myelin protein, organic acids, and defects in energy metabolism, in addition to other causes, (C) 2001 by Elsevier Science Inc. All rights reserved.

引用

页码：11 / 24

页数：14

共 140 条

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