Presentation of BMP-2 from a Soft Biopolymeric Film Unveils its Activity on Cell Adhesion and Migration

被引：119

作者：

Crouzier, Thomas ^{[1
]}

Fourel, Laure ^{[1
]}

Boudou, Thomas ^{[1
]}

Albiges-Rizo, Corinne ^{[2
]}

Picart, Catherine ^{[1
]}

机构：

[1] CNRS INPG, LMGP, F-38016 Grenoble, France

[2] Univ Grenoble 1, Inst Albert Bonniot, INSERM U823, ERL CNRS3148, F-38042 Grenoble 9, France

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 12期

关键词：

BONE MORPHOGENETIC PROTEIN-2; EXTRACELLULAR-MATRIX; GROWTH-FACTORS; OSTEOBLAST LINEAGE; DIFFERENTIATION; INTEGRINS; MICROENVIRONMENTS; BIOMATERIALS; DELIVERY; ACTIVATION;

D O I：

10.1002/adma.201004637

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The dramatic effect of morphogenetic protein 2 (BMP-2), presented to cells in a "matrix bound" manner is described. BMP-2 is either delivered in solution or bound to a thin film made of poly(lysine) and hyaluronan. In this later case only, a striking effect of BMP-2 on cell adhesion and migration is observed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：H111 / H118

页数：8

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