HIV-1 Gag proteins: Diverse functions in the virus life cycle

被引：515

作者：

Freed, EO ^{[1
]}

机构：

[1] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

来源：

VIROLOGY | 1998年 / 251卷 / 01期

关键词：

D O I：

10.1006/viro.1998.9398

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Gag proteins of HIV-I, like those of other retroviruses, are necessary and sufficient for the assembly of virus-like particles. The roles played by HIV-I Gag proteins during the life cycle are numerous and complex, involving not only assembly but also virion maturation after particle release and early postentry steps in virus replication. As the individual Gag domains carry out their diverse functions, they must engage in interactions with themselves, other Gag proteins, other viral proteins, lipid, nucleic acid (DNA and RNA), and host cell proteins. This review briefly summarizes our current understanding of how HIV-I Gag proteins function in the virus life cycle.

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页码：1 / 15

页数：15

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