Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

被引：127

作者：

Simon, Diana ^{[1
]}

Garcia-Garcia, Esther

Royo, Felix ^{[3
]}

Manuel Falcon-Perez, Juan ^{[3
,4
]}

Avila, Jesus ^{[2
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[2] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28031, Spain

[3] Ctr Invest Biomed Red Area Temat Enfermedades Hep, CIC BioGUNE, Metabol Unit, Derio 48160, Bizkaia, Spain

[4] Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain

来源：

FEBS LETTERS | 2012年 / 586卷 / 01期

关键词：

Tau protein; Alzheimer's disease; Membrane vesicles; ALZHEIMERS-DISEASE; EXTRACELLULAR TAU; PHOSPHORYLATION; AGGREGATION; ASSOCIATION; EXOSOMES; PROMOTES; PROTEIN; MECHANISM; FRAGMENT;

D O I：

10.1016/j.febslet.2011.11.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：47 / 54

页数：8

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