ATR: an essential regulator of genome integrity

被引：1352

作者：

Cimprich, Karlene A. ^{[1
]}

Cortez, David ^{[2
]}

机构：

[1] Stanford Univ, Dept Chem & Syst Biol, Clark Ctr, Sch Med, Stanford, CA 94305 USA

[2] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 08期

关键词：

D O I：

10.1038/nrm2450

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.

引用

页码：616 / 627

页数：12

共 182 条

[21] Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
Byun, TS
Pacek, M
Yee, MC
Walter, JC
Cimprich, KA
[J]. GENES & DEVELOPMENT, 2005, 19 (09) : 1040 - 1052
[22] Molecular anatomy and regulation of a stable replisome eukaryotic DNA at a paused replication fork
Calzada, A
Hodgson, B
Kanemaki, M
Bueno, A
Labib, K
[J]. GENES & DEVELOPMENT, 2005, 19 (16) : 1905 - 1919
[23] Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Canman, CE
Lim, DS
Cimprich, KA
Taya, Y
Tamai, K
Sakaguchi, K
Appella, E
Kastan, MB
Siliciano, JD
[J]. SCIENCE, 1998, 281 (5383) : 1677 - 1679
[24] ATR regulates fragile site stability
Casper, AM
Nghiem, P
Arlt, MF
Glover, TW
[J]. CELL, 2002, 111 (06) : 779 - 789
[25] ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
Cha, RS
Kleckner, N
[J]. SCIENCE, 2002, 297 (5581) : 602 - 606
[26] The nonsense-mediated decay RNA surveillance pathway
Chang, Yao-Fu
Imam, J. Saadi
Wilkinson, Miles E.
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2007, 76 : 51 - 74
[27] Function of the ATR N-terminal domain revealed by an ATM/ATR chimera
Chen, Xinping
Zhao, Runxiang
Glick, Gloria G.
Cortez, David
[J]. EXPERIMENTAL CELL RESEARCH, 2007, 313 (08) : 1667 - 1674
[28] Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase
Chiu, CY
Cary, RB
Chen, DJ
Peterson, SR
Stewart, PL
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1998, 284 (04) : 1075 - 1081
[29] Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
Choi, Jun-Hyuk
Lindsey-Boltz, Laura A.
Sancar, Aziz
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (33) : 13301 - 13306
[30] Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
Collins, I
Garrett, MD
[J]. CURRENT OPINION IN PHARMACOLOGY, 2005, 5 (04) : 366 - 373

← 1 2 3 4 5 6 7 8 9 10 →