Simple fragment syntheses of all four isomers of the spermine alkaloid kukoamine

被引：24

作者：

Karigiannis, G

Mamos, P

Balayiannis, G

Katsoulis, I

Papaioannou, D ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, Patras 26500, Greece

[2] Univ Patras, Dept Med, Patras 26500, Greece

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 28期

关键词：

amino acids and derivatives; polyamine; protecting groups; solid-phase synthesis;

D O I：

10.1016/S0040-4039(98)00940-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

All four isomers of the spermine alkaloid kukoamine were unambiguously prepared through diacylation with O.O'-dibenzylcaffeyl chloride of suitably protected (benzyl and/or trityl groups) spermine derivatives, assembled on solid and/or in liquid phase using (beta-alanine and gamma-aminobutyric acid, followed by simultaneous N- and O deprotection and double bond reduction using catalytic hydrogenation. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：5117 / 5120

页数：4

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