Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells

被引:101
作者
Waithman, Jason
Allan, Rhys S.
Kosaka, Hiroshi
Azukizawa, Hiroaki
Shortman, Ken
Lutz, Manfred B.
Heath, William R. [1 ]
Carbone, Francis R.
Belz, Gabrielle T.
机构
[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia
[3] Osaka Minami Med Ctr, Natl Hosp Org, Dept Dermatol, Kawachi Nagano, Japan
[4] Osaka Univ, Sch Med, Dept Dermatol, Suita, Osaka 565, Japan
[5] Univ Wurzburg, Inst Virol & Immunbiol, D-97078 Wurzburg, Germany
基金
英国惠康基金;
关键词
D O I
10.4049/jimmunol.179.7.4535
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Skin-draining lymph nodes contain a number of dendritic cell (DC) subsets of different origins. Some of these are migratory, such as the skin-derived epidermal Langerhans cells and a separate dermal DC subset, whereas others are lymphoid resident in nature, such as the CD8(+) DCs found throughout the lymphoid tissues. In this study, we examine the DC subset presentation of skin-derived self-Ag by migratory and lymphoid-resident DCs, both in the steady state and under conditions of local skin infection. We show that presentation of self-Ag is confined to skin-derived migrating DCs in both settings. Steady state presentation resulted in deletional T cell tolerance despite these DCs expressing a relatively mature phenotype as measured by traditional markers such as the level of MHC class II and CD86 expression. Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool.
引用
收藏
页码:4535 / 4541
页数:7
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