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Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells
被引:101
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Allan, Rhys S.
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机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

Kosaka, Hiroshi
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机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

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Shortman, Ken
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机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

Lutz, Manfred B.
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机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

Heath, William R.
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机构:
Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

Carbone, Francis R.
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机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

Belz, Gabrielle T.
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机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
机构:
[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia
[3] Osaka Minami Med Ctr, Natl Hosp Org, Dept Dermatol, Kawachi Nagano, Japan
[4] Osaka Univ, Sch Med, Dept Dermatol, Suita, Osaka 565, Japan
[5] Univ Wurzburg, Inst Virol & Immunbiol, D-97078 Wurzburg, Germany
基金:
英国惠康基金;
关键词:
D O I:
10.4049/jimmunol.179.7.4535
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Skin-draining lymph nodes contain a number of dendritic cell (DC) subsets of different origins. Some of these are migratory, such as the skin-derived epidermal Langerhans cells and a separate dermal DC subset, whereas others are lymphoid resident in nature, such as the CD8(+) DCs found throughout the lymphoid tissues. In this study, we examine the DC subset presentation of skin-derived self-Ag by migratory and lymphoid-resident DCs, both in the steady state and under conditions of local skin infection. We show that presentation of self-Ag is confined to skin-derived migrating DCs in both settings. Steady state presentation resulted in deletional T cell tolerance despite these DCs expressing a relatively mature phenotype as measured by traditional markers such as the level of MHC class II and CD86 expression. Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool.
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页码:4535 / 4541
页数:7
相关论文
共 42 条
[1]
Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells
[J].
Allan, RS
;
Smith, CM
;
Belz, GT
;
van Lint, AL
;
Wakim, LM
;
Heath, WR
;
Carbone, FR
.
SCIENCE,
2003, 301 (5641)
:1925-1928

Allan, RS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Smith, CM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Belz, GT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

van Lint, AL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Wakim, LM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Heath, WR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia
[2]
Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse
[J].
Anjuère, F
;
Martín, P
;
Ferrero, I
;
Fraga, ML
;
del Hoyo, GM
;
Wright, N
;
Ardavin, C
.
BLOOD,
1999, 93 (02)
:590-598

Anjuère, F
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

Martín, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

Ferrero, I
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

Fraga, ML
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

del Hoyo, GM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

Wright, N
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

Ardavin, C
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain
[3]
Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes
[J].
Azukizawa, H
;
Kosaka, H
;
Sano, S
;
Heath, WR
;
Takahashi, I
;
Gao, XH
;
Sumikawa, Y
;
Okabe, M
;
Yoshikawa, K
;
Itami, S
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2003, 33 (07)
:1879-1888

论文数: 引用数:
h-index:
机构:

Kosaka, H
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan

Sano, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan

Heath, WR
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan

Takahashi, I
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan

Gao, XH
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan

Sumikawa, Y
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan

论文数: 引用数:
h-index:
机构:

Yoshikawa, K
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan

Itami, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Dermatol, Course Mol Med, Suita, Osaka 5650871, Japan
[4]
Dendritic cells and the control of immunity
[J].
Banchereau, J
;
Steinman, RM
.
NATURE,
1998, 392 (6673)
:245-252

Banchereau, J
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Res Inst, Baylor Inst Immunol, Dallas, TX 75246 USA

Steinman, RM
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Res Inst, Baylor Inst Immunol, Dallas, TX 75246 USA
[5]
Cutting edge:: Conventional CD8α+ dendritic cells are generally involved in priming CTL immunity to viruses
[J].
Belz, GT
;
Smith, CM
;
Eichner, D
;
Shortman, K
;
Karupiah, G
;
Carbone, FR
;
Heath, WK
.
JOURNAL OF IMMUNOLOGY,
2004, 172 (04)
:1996-2000

Belz, GT
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Smith, CM
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Eichner, D
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Shortman, K
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

论文数: 引用数:
h-index:
机构:

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Heath, WK
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia
[6]
Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
[J].
Bennett, CL
;
van Rijn, E
;
Jung, S
;
Inaba, K
;
Steinman, RM
;
Kapsenberg, ML
;
Clausen, BE
.
JOURNAL OF CELL BIOLOGY,
2005, 169 (04)
:569-576

Bennett, CL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

van Rijn, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

Jung, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

Inaba, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

Steinman, RM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

Kapsenberg, ML
论文数: 0 引用数: 0
h-index: 0
机构: Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

Clausen, BE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands
[7]
Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
[J].
Bogunovic, Milena
;
Ginhoux, Florent
;
Wagers, Amy
;
Loubeau, Martine
;
Isola, Luis M.
;
Lubrano, Lauren
;
Najfeld, Vesna
;
Phelps, Robert G.
;
Grosskreutz, Celia
;
Scigliano, Eilleen
;
Frenette, Paul S.
;
Merad, Miriam
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2006, 203 (12)
:2627-2638

Bogunovic, Milena
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Ginhoux, Florent
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Wagers, Amy
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Loubeau, Martine
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Isola, Luis M.
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Lubrano, Lauren
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Najfeld, Vesna
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Phelps, Robert G.
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Grosskreutz, Celia
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Scigliano, Eilleen
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Frenette, Paul S.
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

Merad, Miriam
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA
[8]
Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells
[J].
Bosnjak, L
;
Miranda-Saksena, M
;
Koelle, DM
;
Boadle, RA
;
Jones, CA
;
Cunningham, AL
.
JOURNAL OF IMMUNOLOGY,
2005, 174 (04)
:2220-2227

Bosnjak, L
论文数: 0 引用数: 0
h-index: 0
机构: Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia

Miranda-Saksena, M
论文数: 0 引用数: 0
h-index: 0
机构: Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia

Koelle, DM
论文数: 0 引用数: 0
h-index: 0
机构: Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia

Boadle, RA
论文数: 0 引用数: 0
h-index: 0
机构: Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia

Jones, CA
论文数: 0 引用数: 0
h-index: 0
机构: Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia

Cunningham, AL
论文数: 0 引用数: 0
h-index: 0
机构: Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia
[9]
Impaired Langerhans cell migration in psoriasis
[J].
Cumberbatch, M
;
Singh, M
;
Dearman, RJ
;
Young, HS
;
Kimber, I
;
Griffiths, CEM
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2006, 203 (04)
:953-960

Cumberbatch, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England

Singh, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England

Dearman, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England

Young, HS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England

Kimber, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England

Griffiths, CEM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England
[10]
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim
[J].
Davey, GM
;
Kurts, C
;
Miller, JFAP
;
Bouillet, P
;
Strasser, A
;
Brooks, AG
;
Carbone, FR
;
Heath, WR
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2002, 196 (07)
:947-955

Davey, GM
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Kurts, C
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Miller, JFAP
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Bouillet, P
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Strasser, A
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Brooks, AG
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Heath, WR
论文数: 0 引用数: 0
h-index: 0
机构:
PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia