Functional membrane diffusion of G-protein coupled receptors

被引：25

作者：

Baker, Aurelie ^{[1
]}

Sauliere, Aude ^{[1
]}

Dumas, Fabrice ^{[1
]}

Millot, Claire ^{[1
]}

Mazeres, Serge ^{[1
]}

Lopez, Andre ^{[1
]}

Salome, Laurence ^{[1
]}

机构：

[1] Univ Toulouse 2, CNRS, UMR 5089, Int Pharmacol & Biol Struct, F-31077 Toulouse 09, France

来源：

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2007年 / 36卷 / 08期

关键词：

signal transduction; protein interactions; membrane domain; cytoskeleton; FRAP; SPT;

D O I：

10.1007/s00249-007-0214-7

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

G-protein-coupled receptor function involves interactions between the receptor, G-proteins and effectors in the cell plasma membrane. The main biochemical processes have been individually identified but the mechanisms governing the successive protein-protein interactions of this complex multi-molecular machinery have yet to be established. We discuss advances in understanding the functional dynamics of the receptor resulting from diffusion measurements, and in the context of the plasma membrane organization.

引用

页码：849 / 860

页数：12

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