Efficient and practical method for synthesizing optically active γ-trityloxymethyl-α-alkylidene-γ-butyrolactones using Ti(II)-mediated intramolecular nucleophilic acyl substitution reaction

被引：12

作者：

Mincheva, ZP ^{[1
]}

Gao, Y ^{[1
]}

Sato, F ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 43期

关键词：

lactones; epoxides; titanium and compounds; coupling reactions;

D O I：

10.1016/S0040-4039(98)01769-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and highly stereoselective method for synthesizing optically active gamma-trityloxymethyl-alpha-alkylidene-gamma-butyrolactones having a stereodefined mono or disubstituted exocyclic double bond, starting from commercially available non-racemic glycidyl tritylether has been developed in which a titanium(II)-mediated intramolecular nucleophilic acyl substitution reaction is a key reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7947 / 7950

页数：4

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