Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis

被引：17

作者：

Credito, Kim L. ^{[1
]}

Ednie, Lois M. ^{[1
]}

Appelbaum, Peter C. ^{[1
]}

机构：

[1] Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 01期

关键词：

D O I：

10.1128/AAC.00910-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC50 of 0.125 mu g/ml and an MIC90 of 1 mu g/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2 x MIC after 48 h.

引用

页码：365 / 373

页数：9

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