Unrelated-donor cord blood transplantation for adult hematological malignancies

被引：13

作者：

Moscardó, F ^{[1
]}

Sanz, GF ^{[1
]}

Sanz, MA ^{[1
]}

机构：

[1] Hosp Univ La Fe, Dept Hematol, Bone Marrow Transplant Unit, Valencia 46009, Spain

来源：

LEUKEMIA & LYMPHOMA | 2004年 / 45卷 / 01期

关键词：

stem cell transplantation; umbilical cord blood; hematological malignancy;

D O I：

10.1080/1042819031000146992

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Umbilical cord blood (UCB) is potentially an attractive new source of hematopoietic stem cells. The extensive and ready availability of UCB offers important logistical advantages compared with traditional unrelated bone marrow. However, the initial concern about engraftment due to the low number of progenitor cells contained in a UCB unit, has limited the use of UCB, mainly for adult patients. In this review, we summarize the most important data available regarding the main aspects of unrelated-donor cord blood transplantation (UD-CBT) in adult patients. We will review the characteristics of UCB and their practical implications, the outcomes of and clinical results after UD-CBT used for hematological malignancies, and the current advances in UD-CBT designed to optimize this procedure. Current data confirm that UD-CBT is a reasonable alternative for those patients lacking a matched bone-marrow donor.

引用

页码：11 / 18

页数：8

共 61 条

[51] Unrelated donor cord blood transplantation in adults with chronic myelogenous leukemia:: results in nine patients from a single institution [J].

Sanz, GF ;

Saavedra, S ;

Jiménez, C ;

Senent, L ;

Cervera, J ;

Planelles, D ;

Bolufer, P ;

Larrea, L ;

Martín, G ;

Martínez, J ;

Jarque, I ;

Moscardó, F ;

Plumé, G ;

Andreu, R ;

de la Rubia, J ;

Barragán, E ;

Solves, P ;

Soler, MA ;

Sanz, MA .

BONE MARROW TRANSPLANTATION, 2001, 27 (07) :693-701

[52] Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies [J].

Sanz, GF ;

Saavedra, S ;

Planelles, D ;

Senent, L ;

Cervera, J ;

Barragán, E ;

Jiménez, C ;

Larrea, L ;

Martín, G ;

Martínez, J ;

Jarque, I ;

Moscardó, F ;

Plumé, G ;

Andreu, R ;

Regadera, AI ;

García, I ;

Mollá, S ;

Solves, P ;

de la Rubia, J ;

Bolufer, P ;

Benlloch, L ;

Soler, MA ;

Marty, ML ;

Sanz, MA .

BLOOD, 2001, 98 (08) :2332-2338

[53] Ex vivo expansion of megakaryocyte precursors from umbilical cord blood CD34+ cells in a closed liquid culture system [J].

Shaw, PH ;

Gilligan, D ;

Wang, XM ;

Thall, PF ;

Corey, SJ .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2003, 9 (03) :151-156

[54] Transplantation of ex vivo expanded cord blood [J].

Shpall, EJ ;

Quinones, R ;

Giller, R ;

Zeng, C ;

Barón, AE ;

Jones, RB ;

Bearman, SI ;

Nieto, Y ;

Freed, B ;

Madinger, N ;

Hogan, CJ ;

Slat-Vazquez, V ;

Russell, P ;

Blunk, B ;

Schissel, D ;

Hild, E ;

Malcolm, J ;

Ward, W ;

McNiece, IK .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (07) :368-376

[55] CONGENITAL CYTOMEGALOVIRUS-INFECTION - THE RELATIVE IMPORTANCE OF PRIMARY AND RECURRENT MATERNAL INFECTION [J].

STAGNO, S ;

PASS, RF ;

DWORSKY, ME ;

HENDERSON, RE ;

MOORE, EG ;

WALTON, PD ;

ALFORD, CA .

NEW ENGLAND JOURNAL OF MEDICINE, 1982, 306 (16) :945-949

[56] PRIMARY CYTOMEGALOVIRUS-INFECTION IN PREGNANCY - INCIDENCE, TRANSMISSION TO FETUS, AND CLINICAL OUTCOME [J].

STAGNO, S ;

PASS, RF ;

CLOUD, G ;

BRITT, WJ ;

HENDERSON, RE ;

WALTON, PD ;

VEREN, DA ;

PAGE, F ;

ALFORD, CA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1986, 256 (14) :1904-1908

[57] METHOTREXATE AND CYCLOSPORINE COMPARED WITH CYCLOSPORINE ALONE FOR PROPHYLAXIS OF ACUTE GRAFT VERSUS HOST-DISEASE AFTER MARROW TRANSPLANTATION FOR LEUKEMIA [J].

STORB, R ;

DEEG, HJ ;

WHITEHEAD, J ;

APPELBAUM, F ;

BEATTY, P ;

BENSINGER, W ;

BUCKNER, CD ;

CLIFT, R ;

DONEY, K ;

FAREWELL, V ;

HANSEN, J ;

HILL, R ;

LUM, L ;

MARTIN, P ;

MCGUFFIN, R ;

SANDERS, J ;

STEWART, P ;

SULLIVAN, K ;

WITHERSPOON, R ;

YEE, G ;

THOMAS, ED .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (12) :729-735

[58] Human stem-progenitor cells from neonatal cord blood have greater hematopoietic expansion capacity than those from mobilized adult blood [J].

Tanavde, VM ;

Malehorn, MT ;

Lumkul, R ;

Gao, ZG ;

Wingard, J ;

Garrett, ES ;

Civin, CI .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (07) :816-823

[59] EVIDENCE FOR A MITOTIC CLOCK IN HUMAN HEMATOPOIETIC STEM-CELLS - LOSS OF TELOMERIC DNA WITH AGE [J].

VAZIRI, H ;

DRAGOWSKA, W ;

ALLSOPP, RC ;

THOMAS, TE ;

HARLEY, CB ;

LANSDORP, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9857-9860

[60] Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival [J].

Wagner, JE ;

Barker, JN ;

DeFor, TE ;

Baker, KS ;

Blazar, BR ;

Eide, C ;

Goldman, A ;

Kersey, J ;

Krivit, W ;

MacMillan, ML ;

Orchard, PJ ;

Peters, C ;

Weisdorf, DJ ;

Ramsay, NKC ;

Davies, SM .

BLOOD, 2002, 100 (05) :1611-1618

← 1 2 3 4 5 6 7 →