Positive selection of CD4(+) and CD8(+) T cells

被引:50
作者
Guidos, CJ
机构
[1] Division of Immunology and Cancer, Hosp. for Sick Children Res. Inst., Toronto, Ont. M5G 1X8
关键词
D O I
10.1016/S0952-7915(96)80061-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Significant progress has been made in characterizing intermediates and defining individual steps of positive selection, providing important insights into mechanisms of CD4/CD8 lineage commitment. New evidence suggests that specific recognition of peptides may be important for positive selection of CD4+ T cells. Several studies have defined signal-transduction pathways important for positive selection and have provided evidence that distinct signaling pathways may regulate positive versus negative selection.
引用
收藏
页码:225 / 232
页数:8
相关论文
共 53 条
  • [1] SELECTIVE REQUIREMENT FOR MAP KINASE ACTIVATION IN THYMOCYTE DIFFERENTIATION
    ALBEROLAILA, J
    FORBUSH, KA
    SEGER, R
    KREBS, EG
    PERLMUTTER, RM
    [J]. NATURE, 1995, 373 (6515) : 620 - 623
  • [2] ANDERSON G, 1995, J IMMUNOL, V154, P3636
  • [3] INVOLVEMENT OF THE PROTEIN-TYROSINE KINASE P56(LCK) IN T-CELL SIGNALING AND THYMOCYTE DEVELOPMENT
    ANDERSON, SJ
    LEVIN, SD
    PERLMUTTER, RM
    [J]. ADVANCES IN IMMUNOLOGY, VOLUME 56, 1994, 56 : 151 - 178
  • [4] DEFECTIVE T-CELL RECEPTOR SIGNALING AND CD8(+) THYMIC SELECTION IN HUMANS LACKING ZAP-70 KINASE
    ARPAIA, E
    SHAHAR, M
    DADI, H
    COHEN, A
    ROIFMAN, CM
    [J]. CELL, 1994, 76 (05) : 947 - 958
  • [5] POSITIVE SELECTION OF MOUSE NK1(+) T-CELLS BY CD1-EXPRESSING CORTICAL THYMOCYTES
    BENDELAC, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) : 2091 - 2096
  • [6] CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES
    BENDELAC, A
    LANTZ, O
    QUIMBY, ME
    YEWDELL, JW
    BENNINK, JR
    BRUTKIEWICZ, RR
    [J]. SCIENCE, 1995, 268 (5212) : 863 - 865
  • [7] EXCLUSION AND INCLUSION OF ALPHA-T-CELL AND BETA-T-CELL RECEPTOR ALLELES
    BORGULYA, P
    KISHI, H
    UEMATSU, Y
    VONBOEHMER, H
    [J]. CELL, 1992, 69 (03) : 529 - 537
  • [8] TAP-INDEPENDENT, BETA(2)-MICROGLOBULIN-DEPENDENT SURFACE EXPRESSION OF FUNCTIONAL-MOUSE CD1.1
    BRUTKIEWICZ, RR
    BENNINK, JR
    YEWDELL, JW
    BENDELAC, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) : 1913 - 1919
  • [9] ZAP-70 DEFICIENCY IN AN AUTOSOMAL RECESSIVE FORM OF SEVERE COMBINED IMMUNODEFICIENCY
    CHAN, AC
    KADLECEK, TA
    ELDER, ME
    FILIPOVICH, AH
    KUO, WL
    IWASHIMA, M
    PARSLOW, TG
    WEISS, A
    [J]. SCIENCE, 1994, 264 (5165) : 1599 - 1601
  • [10] ROLE OF CORECEPTORS IN POSITIVE SELECTION AND LINEAGE COMMITMENT
    CHAN, SH
    WALTZINGER, C
    BARON, A
    BENOIST, C
    MATHIS, D
    [J]. EMBO JOURNAL, 1994, 13 (19) : 4482 - 4489