Cyclooxygenase-1 and-2 expression in urothelial carcinomas of the urinary bladder in cows

被引:26
作者
Borzacchiello, G
Ambrosio, V
Galati, P
Perillo, A
Roperto, F [1 ]
机构
[1] Univ Naples Federico II, Dept Pathol & Anim Hlth, Gen Pathol Div, Fac Med Vet, Naples, Italy
[2] Univ Bari, Fac Med Vet, Div Anat Pathol, Dept Hlth & Anim Well Being, Bari, Italy
关键词
bracken fern; cows; COX-1; COX-2; confocal laser scanning microscopy; ptaquiloside; urothelial carcinoma;
D O I
10.1354/vp.40-4-455
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Bovine urinary bladder tumors occur frequently in animals suffering from chronic enzootic hematuria because of prolonged ingestion of bracken fern (Pteridium spp.). Cyclooxygenase (COX) genes (COX-1 and COX-2) are known to be involved in the carcinogenesis of human and some animal urothelial tumors. The aim of the present study was to investigate COX-1 and COX-2 expression by inummohistochemical methods in 20 bovine urothelial carcinomas collected at public slaughterhouses from cows that had been suffering from chronic enzootic hematuria. COX-1 immunostaining was identified intracytoplasmically in normal urothelium and in 15 of 20 neoplastic specimens. COX-1 immunosignal in the tumor cells was either absent or weak. COX-2 was also expressed intracytoplasmically in 17 of 20 urothelial carcinomas. Moderate to intense COX-2 labeling was detected in both noninvasive and invasive urothelial carcinomas. Coexpression of both enzyme isoforms was also revealed by confocal laser scanning microscopic investigations. This study indicates that COX-2 is overexpressed in naturally occurring urothelial carcinomas of cows.
引用
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页码:455 / 459
页数:5
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