Cyclooxygenase-1 and-2 expression in urothelial carcinomas of the urinary bladder in cows
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Borzacchiello, G
Ambrosio, V
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机构:Univ Naples Federico II, Dept Pathol & Anim Hlth, Gen Pathol Div, Fac Med Vet, Naples, Italy
Ambrosio, V
Galati, P
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机构:Univ Naples Federico II, Dept Pathol & Anim Hlth, Gen Pathol Div, Fac Med Vet, Naples, Italy
Galati, P
Perillo, A
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机构:Univ Naples Federico II, Dept Pathol & Anim Hlth, Gen Pathol Div, Fac Med Vet, Naples, Italy
Perillo, A
Roperto, F
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Univ Naples Federico II, Dept Pathol & Anim Hlth, Gen Pathol Div, Fac Med Vet, Naples, ItalyUniv Naples Federico II, Dept Pathol & Anim Hlth, Gen Pathol Div, Fac Med Vet, Naples, Italy
Roperto, F
[1
]
机构:
[1] Univ Naples Federico II, Dept Pathol & Anim Hlth, Gen Pathol Div, Fac Med Vet, Naples, Italy
[2] Univ Bari, Fac Med Vet, Div Anat Pathol, Dept Hlth & Anim Well Being, Bari, Italy
Bovine urinary bladder tumors occur frequently in animals suffering from chronic enzootic hematuria because of prolonged ingestion of bracken fern (Pteridium spp.). Cyclooxygenase (COX) genes (COX-1 and COX-2) are known to be involved in the carcinogenesis of human and some animal urothelial tumors. The aim of the present study was to investigate COX-1 and COX-2 expression by inummohistochemical methods in 20 bovine urothelial carcinomas collected at public slaughterhouses from cows that had been suffering from chronic enzootic hematuria. COX-1 immunostaining was identified intracytoplasmically in normal urothelium and in 15 of 20 neoplastic specimens. COX-1 immunosignal in the tumor cells was either absent or weak. COX-2 was also expressed intracytoplasmically in 17 of 20 urothelial carcinomas. Moderate to intense COX-2 labeling was detected in both noninvasive and invasive urothelial carcinomas. Coexpression of both enzyme isoforms was also revealed by confocal laser scanning microscopic investigations. This study indicates that COX-2 is overexpressed in naturally occurring urothelial carcinomas of cows.
机构:
Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Tokyo 1130033, JapanUniv Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Tokyo 1130033, Japan
Taketo, MM
[J].
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE,
1998,
90
(21):
: 1609
-
1620
机构:
Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Bunkyo Ku, Tokyo 113, JapanUniv Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Bunkyo Ku, Tokyo 113, Japan
机构:
Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Tokyo 1130033, JapanUniv Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Tokyo 1130033, Japan
Taketo, MM
[J].
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE,
1998,
90
(21):
: 1609
-
1620
机构:
Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Bunkyo Ku, Tokyo 113, JapanUniv Tokyo, Grad Sch Pharmaceut Sci, Lab Biomed Genet, Bunkyo Ku, Tokyo 113, Japan