Modulation of GABAA receptor activity by phosphorylation and receptor trafficking:: implications for the efficacy of synaptic inhibition

被引：223

作者：

Kittler, JT

Moss, SJ

机构：

[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England

[2] UCL, Dept Pharmacol, London WC1E 6BT, England

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 03期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0959-4388(03)00064-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fast synaptic inhibition in the brain is largely mediated by GABA(A) receptors. These ligand-gated ion channels are crucial in the control of cell and network activity. Therefore, modulating their function or cell surface stability will have major consequences for neuronal excitation. It has become clear that the stability and activity of GABAA receptors at synapses can be dynamically modulated by receptor trafficking and phosphorylation. Here, we discuss these regulatory mechanisms, and their consequences for the efficacy of GABAA receptor mediated synaptic inhibition.

引用

收藏

页码：341 / 347

页数：7

相关论文

共 53 条

[11] GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway [J].

Brandon, NJ ;

Delmas, P ;

Kittler, JT ;

McDonald, BJ ;

Sieghart, W ;

Brown, DA ;

Smart, TG ;

Moss, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (49) :38856-38862

[12] BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABAA receptor surface expression [J].

Brünig, I ;

Penschuck, S ;

Berninger, B ;

Benson, J ;

Fritschy, JM .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (07) :1320-1328

[13]

Cai X, 2002, J PHYSIOL-LONDON, V540, P743

[14] Ethanol tolerance and synaptic plasticity [J].

Chandler, LJ ;

Harris, RA ;

Crews, FT .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1998, 19 (12) :491-495

[15] The γ-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics [J].

Chen, L ;

Wang, HB ;

Vicini, S ;

Olsen, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11557-11562

[16] Cell surface stability of γ-aminobutyric acid type A receptors -: Dependence on protein kinase C activity and subunit composition [J].

Connolly, CN ;

Kittler, JT ;

Thomas, P ;

Uren, JM ;

Brandon, NJ ;

Smart, TG ;

Moss, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (51) :36565-36572

[17] Structure of GABARAP in two conformations:: Implications for GABAA receptor localization and tubulin binding [J].

Coyle, JE ;

Qamar, S ;

Rajashankar, KR ;

Nikolov, DB .

NEURON, 2002, 33 (01) :63-74

[18] Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin [J].

Essrich, C ;

Lorez, M ;

Benson, JA ;

Fritschy, JM ;

Lüscher, B .

NATURE NEUROSCIENCE, 1998, 1 (07) :563-571

[19] Serotonin receptors modulate GABAA receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons [J].

Feng, J ;

Cai, X ;

Zhao, JH ;

Yan, Z .

JOURNAL OF NEUROSCIENCE, 2001, 21 (17) :6502-6511

[20] Long-term plasticity at GABAergic and glycinergic synapses: mechanisms and functional significance [J].

Gaiarsa, JL ;

Caillard, O ;

Ben-Ari, Y .

TRENDS IN NEUROSCIENCES, 2002, 25 (11) :564-570

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