Stereochemical control of both C-C and C-N axial chirality in the synthesis of chiral N,O-biaryls

被引：95

作者：

Oppenheimer, Jossian ^{[1
]}

Hsung, Richard P. ^{[1
]}

Figueroa, Ruth ^{[1
]}

Johnson, Whitney L. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Div Pharmaceut Sci, Madison, WI 53705 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 20期

关键词：

D O I：

10.1021/ol701692m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(l)-catalyzed asymmetric [2 + 2 + 2] cycloaddition of achiral ynamides is described here. This work demonstrates a unique concept of stereochemical control of both the C-C and C-N axial chirality and provides an approach to the synthesis of chiral N,O-biaryls as well as chiral anilides.

引用

页码：3969 / 3972

页数：4

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