Wound Macrophages as Key Regulators of Repair Origin, Phenotype, and Function

被引:386
作者
Brancato, Samielle K. [1 ]
Albina, Jorge E. [1 ]
机构
[1] Brown Univ, Dept Surg, Div Surg Res, Alpert Med Sch, Providence, RI 02912 USA
基金
美国国家卫生研究院;
关键词
CHEMOKINE RECEPTOR CX3CR1; ENDOTHELIAL GROWTH-FACTOR; ISCHEMIA-REPERFUSION INJURY; CELLS IN-VIVO; DENDRITIC CELLS; LYMPH-NODES; PULMONARY-FIBROSIS; GRANULATION-TISSUE; HEALING WOUNDS; T-CELLS;
D O I
10.1016/j.ajpath.2010.08.003
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Recent results call for the reexamination of the phenotype of wound macrophages and their role in tissue repair. These results include the characterization of distinct circulating monocyte populations with temporally restricted capacities to migrate into wounds and the observation that the phenotype of macrophages isolated from murine wounds partially reflects those of their precursor monocytes, changes with time, and does not conform to current macrophage classifications. Moreover, findings in genetically modified mice lacking macrophages have confirmed that these cells are essential to normal wound healing because their depletion results in retarded and abnormal repair. This mini-review focuses on current knowledge of the phenotype of wound macrophages, their origin and fate, and the specific macrophage functions that underlie their reparative role in injured tissues, including the regulation of the cellular infiltration of the wound and the production of transforming growth factor-beta and vascular endothelial growth factor. (Am J Pathol 2011, 178:19-25; DOI: 10.1016/j.ajpath.2010.08.003)
引用
收藏
页码:19 / 25
页数:7
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